{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:27:40Z","timestamp":1792528060622,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T00:00:00Z","timestamp":1267747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Repeated administration of psychostimulants to rodents can lead to behavioral sensitization. Previous studies, using nonspecific opioid receptor (OR) antagonists, revealed that ORs were involved in modulation of behavioral sensitization to methamphetamine (METH). However, the contribution of OR subtypes remains unclear. In the present study, using \u03bc\u2010OR knockout mice, we examined the role of \u03bc\u2010OR in the development of METH sensitization. Mice received daily intraperitoneal injection of drug or saline for 7 consecutive days to initiate sensitization. To express sensitization, animals received one injection of drug (the same as for initiation) or saline on day 11. Animal locomotor activity and stereotypy were monitored during the periods of initiation and expression of sensitization. Also, the concentrations of METH and its active metabolite amphetamine in the blood were measured after single and repeated administrations of METH. METH promoted significant locomotor hyperactivity at low doses and stereotyped behaviors at relative high doses (2.5 mg\/kg and above). Repeated administration of METH led to the initiation and expression of behavioral sensitization in wild\u2010type mice. METH\u2010induced behavioral responses were attenuated in the \u03bc\u2010OR knockout mice. Haloperidol (a dopamine receptor antagonist) showed a more potent effect in counteracting METH\u2010induced stereotypy in the \u03bc\u2010OR knockout mice. Saline did not induce behavioral sensitization in either genotype. No significant difference was observed in disposition of METH and amphetamine between the two genotypes. Our study indicated that the \u03bc\u2010opioid system is involved in modulating the development of behavioral sensitization to METH. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22386","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T20:20:20Z","timestamp":1267820420000},"page":"2294-2302","source":"Crossref","is-referenced-by-count":54,"title":["\u03bc\u2010Opioid receptor knockout mice are insensitive to methamphetamine\u2010induced behavioral sensitization"],"prefix":"10.1002","volume":"88","author":[{"given":"Xine","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Purser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Tai","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Tso","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horace H.","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(96)00164-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90118-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.05.028"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(72)90136-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90167-G"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0022-3565(25)24578-5","article-title":"Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats","volume":"244","author":"Di Chiara G","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00108-2"},{"key":"e_1_2_6_9_1","first-page":"549","volume-title":"Principles of neuropsychopharmacology","author":"Feldman RS","year":"1997"},{"key":"e_1_2_6_10_1","first-page":"359","volume-title":"Toxicology: a case\u2010oriented approach","author":"Fenton JJ","year":"2002"},{"key":"e_1_2_6_11_1","unstructured":"HodlerC PaquetB GilbertF DroletG LevesqueD RouillardC.2005.Role of endogenous enkephalin and dynorphin in amphetamine\u2010induced behavioral sensitization. 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