{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:29Z","timestamp":1792084109904,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generation of reactive oxygen species (ROS) is a common denominator in many conditions leading to cell death in the cochlea, yet little is known of the cochlea's endogenous mechanisms involved in preventing oxidative stress and its consequences in the cochlea. We have recently described a corticotropin\u2010releasing factor (CRF) signaling system in the inner ear involved in susceptibility to noise\u2010induced hearing loss. We use biochemical and proteomics assays to define further the role of CRF signaling in the response of cochlear cells to aminoglycoside exposure. We demonstrate that activity via the CRF<jats:sub>2<\/jats:sub> class of receptors protects against aminoglycoside\u2010induced ROS production and activation of cell death pathways. This study suggests for the first time a role for CRF signaling in protecting the cochlea against oxidative stress, and our proteomics data suggest novel mechanisms beyond induction of free radical scavengers that are involved in its protective mechanisms. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22449","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T20:31:28Z","timestamp":1276288288000},"page":"2976-2990","source":"Crossref","is-referenced-by-count":14,"title":["Corticotropin\u2010releasing factor\u20102 activation prevents gentamicin\u2010induced oxidative stress in cells derived from the inner ear"],"prefix":"10.1002","volume":"88","author":[{"given":"Johnvesly","family":"Basappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevin","family":"Turcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2005.02.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(99)00183-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.12.8508"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1529"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0689"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-007-9029-y"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(91)90104-H"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90107-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700316"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08532.2002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00712.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900510"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.159"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.01.014"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.11.012"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aud.0000191942.36672.f3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709124984"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00214-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401706"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076807"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1998.0339"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071059"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08641.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4985-05.2006"},{"key":"e_1_2_5_26_1","first-page":"57","article-title":"Fine\u2010needle aspiration biopsy\u2010RT\u2010PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers?","volume":"54","author":"Letsas KP","year":"2007","journal-title":"Neoplasma"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903550307"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/y05-033"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-3-4"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410175200"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1523\/JNEUROSCI.22-04-01218.2002","article-title":"Inhibition of caspases prevents ototoxic and ongoing hair cell death","volume":"22","author":"Matsui J","year":"2002","journal-title":"J Neurosci"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1523\/JNEUROSCI.23-14-06111.2003","article-title":"Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo","volume":"23","author":"Matsui JI","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(96)00170-0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<101::AID-CNE7>3.0.CO;2-L"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00018-4"},{"key":"e_1_2_5_36_1","first-page":"49","article-title":"The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise\u2010induced hearing loss in mice","volume":"3","author":"McFadden S","year":"2001","journal-title":"Noise Health"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(92)90017-H"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200305230-00024"},{"key":"e_1_2_5_39_1","unstructured":"OliverosJC.2007. VENNY. An interactive tool for comparing lists with Venn diagrams.http:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html."},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400129-MCP200"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.26.040186.000455"},{"key":"e_1_2_5_42_1","doi-asserted-by":"crossref","first-page":"ORL354","DOI":"10.1177\/019459987808600229","article-title":"Stria vascularis pathology and recovery following noise exposure","volume":"86","author":"Santi PA","year":"1978","journal-title":"Otolaryngology"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01930-7"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.T600050-MCP200"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08686.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0850rev"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(92)90008-B"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20145"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9504"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-007-0254-7"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.007"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199802160-00014"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00035"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng914"},{"key":"e_1_2_5_56_1","first-page":"345","volume-title":"Methods in molecular biology","author":"Vetter DE","year":"2009"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509121877"},{"key":"e_1_2_5_58_1","article-title":"Nucleolin\/C23 is a negative regulator of hydrogen peroxide\u2010induced apoptosis in HUVECs","author":"Zhang B","year":"2009","journal-title":"Cell Stress Chaperones"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.22449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.22449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:10:10Z","timestamp":1700561410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.22449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,3]]},"references-count":57,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/jnr.22449"],"URL":"https:\/\/doi.org\/10.1002\/jnr.22449","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,3]]}}}