{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:31:33Z","timestamp":1773214293340,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T00:00:00Z","timestamp":1286496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of matrix metalloproteinases (MMPs) and cytokines in the pathogenesis of Guillain\u2010Barr\u00e9 syndrome (GBS) largely remains unknown. We studied the role of MMP\u20102, MMP\u20109, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and interleukin\u20101\u03b2 (IL\u20101\u03b2) in disease progression and recovery of patients with GBS. Sixty\u2010five patients with GBS and 68 healthy controls were enrolled in the study. Serum levels of MMP\u20102, MMP\u20109, TNF\u2010\u03b1, and IL\u20101\u03b2 were analyzed by ELISA, and activities of MMPs were measured by zymography. Expression of MMP\u20109, TNF\u2010\u03b1, and IL\u20101\u03b2 was higher in the progressive phase and lower in the recovery phase of GBS than in controls. A positive correlation of MMP\u20102 with IL\u20101\u03b2 and MMP\u20109 with TNF\u2010\u03b1 and IL\u20101\u03b2 was observed with progressive\u2010phase GBS. The study shows that up\u2010regulation of MMP\u20109 along with proinflammatory cytokines (TNF\u2010\u03b1 and IL\u20101\u03b2) in the early course appears to be associated with immune\u2010mediated disease progression resulting from inflammation in the peripheral nervous system, whereas, during the later phase, down\u2010regulation of MMP\u20109 and proinflammatory cytokines is implicated in recovery from the disease. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22514","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T20:13:49Z","timestamp":1286568829000},"page":"3540-3546","source":"Crossref","is-referenced-by-count":29,"title":["Correlation of matrix metalloproteinases\u20102 and \u20109 with proinflammatory cytokines in Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"88","author":[{"given":"Kishan 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