{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:43:39Z","timestamp":1773891819243,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T00:00:00Z","timestamp":1302566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow\u2010derived stem\/progenitor cells (CD34<jats:sup>+<\/jats:sup> progenitor cells) were demonstrated to play an important role in the regeneration of damaged brain tissue. Our aim was to study the influence of CD34<jats:sup>+<\/jats:sup> progenitor cells in the outcome of intracerebral hemorrhage (ICH). Thirty\u2010two patients with primary ICH (64.0% male, mean age 67.1 \u00b1 10.8 years) were prospectively included in the study within 12 hr of symptom onset. The main outcome variable was good functional outcome at 3 months (modified Rankin scale \u22642). Circulating CD34<jats:sup>+<\/jats:sup> progenitor cell levels were measured by flow cytometry at admission and at 7 \u00b1 1 days, and serum levels of growth factors (determined by ELISA) were measured at admission and at 24 and 72 hr. Circulating levels of CD34<jats:sup>+<\/jats:sup> progenitor cells at day 7 were independently associated with good functional outcome at 3 months (OR 1.17, CI95% 1.06\u20131.39, <jats:italic>P<\/jats:italic> = 0.012). On the other hand, CD34<jats:sup>+<\/jats:sup> progenitor cells at day 7 were negatively correlated with residual cavity volume at 3 months (r = \u20130.607, <jats:italic>P<\/jats:italic> = 0.001). Serum levels of vascular endothelial growth factor (r = 0.386), angiopoietin 1 (r = 0.518), brain\u2010derived neurotrophic factor (r = 0.484), and stromal cell\u2010derived factor\u20101\u03b1 (r = 0.837) but not granulocyte\u2010colony stimulating factor (r = \u20130.038) at 72 hr showed a strong correlation with CD34<jats:sup>+<\/jats:sup> progenitor cell levels at day 7. These findings suggest that CD34<jats:sup>+<\/jats:sup> progenitor cells may participate in the functional recovery of ICH patients. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22627","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T14:29:45Z","timestamp":1302618585000},"page":"979-985","source":"Crossref","is-referenced-by-count":29,"title":["Cd34<sup>+<\/sup>progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans"],"prefix":"10.1002","volume":"89","author":[{"given":"Tom\u00e1s","family":"Sobrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"P\u00e9rez\u2010Mato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Agulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Brea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Rodr\u00edguez\u2010Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3964"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.183689"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.178"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.499236"},{"key":"e_1_2_5_6_1","volume-title":"Gu\u00eda para el diagn\u00f3stico y tratamiento del ictus","year":"2006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.044"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.9.1005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.1.84"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000240248.55172.dd"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522655"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104X3789"},{"key":"e_1_2_5_13_1","first-page":"755","article-title":"[Morbidity due to intracerebral hemorrhage]","volume":"27","author":"Lopez\u2010Gonzalez FJ","year":"1998","journal-title":"Rev Neurol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(05)70233-6","article-title":"Early surgery vs. initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the international surgical trial in intracerebral haemorrhage (stich): a randomised trial","volume":"365","author":"Mendelow AD","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.067"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441907"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65365-5"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.2.313"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.080"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.127746"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.484386"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.182"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn566"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.535757"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.11.068"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000055313.77510.22"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489401"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X91960"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9911-6"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.22627","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.22627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:30:10Z","timestamp":1700566210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.22627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,12]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/jnr.22627"],"URL":"https:\/\/doi.org\/10.1002\/jnr.22627","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,12]]}}}