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Six\u2010month\u2010old mice on a mixed C57Bl6 \u00d7 129 background were anesthetized with isoflurane and exposed to unilateral noise (n = 15), or sham exposure for controls (n = 8), for 1 hr (16\u2010kHz octave band signal, 116\u2010dB SPL). Tinnitus was tested in eight different sound frequency bands before and at postexposure time points of 1, 3\u20134, 7, 14, 21, and 30 days and monthly thereafter until 7 months postexposure. Noise\u2010exposed mice displayed a number of changes in GPIAS consistent with the presence of hyperacusis and tinnitus. Noise exposure was associated with acute tinnitus measured 1 day later at several frequencies at and above the exposure frequency center. Consistent, chronic tinnitus then emerged in the 24\u2010kHz range. Several time points following noise exposure suggested evidence of hyperacusis, often followed temporally by the development of deficits in GPIAS (reflecting tinnitus). Temporal development of these changes following noise exposure are discussed in the context of the interactions among aging, noise exposure, and the associated neurochemical changes that occur at early stages of auditory processing. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22827","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T14:10:37Z","timestamp":1332425437000},"page":"1480-1488","source":"Crossref","is-referenced-by-count":73,"title":["Time course of tinnitus development following noise exposure in mice"],"prefix":"10.1002","volume":"90","author":[{"given":"Jeremy","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deb","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"Moechars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010030"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70237-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810140081011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00368.x"},{"key":"e_1_2_6_6_1","unstructured":"Department of Veterans Affairs Veterans Benefits Administration.2009. 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