{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:06Z","timestamp":1791293166193,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the gene <jats:italic>MECP2<\/jats:italic> encoding the methyl\u2010CpG binding protein 2. This genetic disease affects predominantly girls and is characterized by a period of normal development that lasts for 8\u201318 months, followed by neurologic regression affecting both motor and mental abilities. Previous studies performed on brains from RTT subjects and Mecp2\u2010deficient mice showed striking changes in neuronal maturation and dendritic arborization. Recently, we showed that expression of stathmin\u2010like 2 (STMN2) was significantly reduced in fibroblasts from RTT patients, and similar results were obtained in the cerebellum of Mecp2\u2010deficient mice. Because assembly and dynamics of microtubules are known to be modulated by STMN2, we studied microtubule dynamics in brain cells from Mecp2\u2010deficient mice. We observed that Mecp2 deficiency affects microtubule dynamics in astrocytes from Mecp2\u2010deficient mice. Our data reinforce the fact that the loss of Mecp2 in astrocytes may influence the onset and progression of RTT. These results imply that Mecp2 has a stabilizing role in microtubule dynamics and that Mecp2 deficiency, which is associated with STMN2 down\u2010regulation, could lead to impaired microtubule stability, hence explaining the dendritic abnormalities observed in RTT brains. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23001","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T11:27:33Z","timestamp":1326886053000},"page":"990-998","source":"Crossref","is-referenced-by-count":27,"title":["Altered microtubule dynamics in Mecp2\u2010deficient 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