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The aim of this work was to evaluate the effectiveness of pulsed therapeutic ultrasound (TU) on an experimental rat model of trigeminal neuropathic nociception (chronic constriction injury\u2014infraorbital nerve; CCI\u2010ION). To evaluate facial thermonociception, an apparatus that measured the reaction time for head withdrawal was constructed. After surgery, a gradual reduction in reaction time was observed until day 15 post\u2010CCI, when the values became constant. Three ipsilateral applications of TU to post\u2010CCI rats promoted an increase in latency time. This antinociceptive effect was evident even after the first TU application, reaching maximal values at 24 hr. The magnitude of this effect was proportional to ultrasonic wave intensity (0.3 and 0.4 W\/cm<jats:sup>2<\/jats:sup>). Posttreatment with naltrexone (5 mg\/kg, s.c.) completely blocked the hypoalgesic effect of TU. Pretreatment with an opioid antagonist was unable to block the antinociceptive effect during the first 8 hr, suggesting that opioids are involved only in the latter phase of the TU effects. Myeloperoxidase (MPO) levels in the infraorbital nerve were not increased by TU use, indicating that TU causes no injury or is at least insufficient to induce neutrophil migration. In conclusion, TU is an effective resource in a model of trigeminal neuropathic pain, with a mechanism involving opioid receptor activation, confirming its potential usefulness in the treatment of trigeminal neuralgia. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23056","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T13:09:56Z","timestamp":1337087396000},"page":"1639-1645","source":"Crossref","is-referenced-by-count":12,"title":["Assay of therapeutic ultrasound induced\u2010antinociception in experimental trigeminal neuropathic pain"],"prefix":"10.1002","volume":"90","author":[{"given":"\u00c1tila","family":"Savernini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha","family":"Savernini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Almeida","family":"de 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