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Overall, positive associations of the IL\u20101A \u2212889C\/T polymorphism with AD risk were found in allele comparison T vs. C (OR = 1.09, 95% CI = 1.01\u20131.18), recessive model TT vs. CT + CC (OR = 1.21, 95% CI = 1.01\u20131.45), and homozygote comparison (TT vs. CC; OR = 1.32, 95% CI = 1.04\u20131.67). In subgroup analysis stratified by ethnicity, significant associations were demonstrated in Caucasians but not in Asians. In subgroup analysis according to the age of onset, the data showed a significant association in patients with late\u2010onset AD in Caucasians but not in early\u2010onset AD. In conclusion, this meta\u2010analysis supports the idea that IL\u20101A \u2013889C\/T polymorphism is capable of causing AD and LOAD susceptibility in Caucasians but not in Asians. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23062","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T11:00:13Z","timestamp":1334833213000},"page":"1681-1692","source":"Crossref","is-referenced-by-count":8,"title":["Meta\u2010analysis of the association between the interleukin\u20101A \u2212889C\/T polymorphism and Alzheimer's 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