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Injury was induced by partial occlusion of umbilical cord for 60 min, and then the preterm lambs (80\u201390% of gestation) were randomly assigned to one of the following groups: control group, in which the animals were managed by conventional mechanical ventilation for 3 hr; 3 hr postpartial cord occlusion (3\u2010hr\u2010PCO) group, in which injured animals were managed by ventilation and then sacrificed 3 hr after HI; and MgSO<jats:sub>4<\/jats:sub> group, in which animals received 400 mg\/kg MgSO<jats:sub>4<\/jats:sub> for 20 min soon after HI was induced and were managed by ventilation for 3 hr. Brains were analyzed for apoptosis by TUNEL assay. Cell viability and intracellular state studies were assessed by flow cytometry. The delayed death index was significantly increased in the 3\u2010hr\u2010PCO group in comparison with control. Administration of MgSO<jats:sub>4<\/jats:sub> elicited a delay in cell death that was similar to that in the control group. The 3\u2010hr\u2010PCO group showed a significantly higher concentration of reactive oxygen species, mitochondrial damage, and intracellular calcium in comparison with control and MgSO<jats:sub>4<\/jats:sub>\u2010 treated groups. Our results suggest that MgSO<jats:sub>4<\/jats:sub> treatment might have potential therapeutic benefits after the HI event. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23091","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T09:39:22Z","timestamp":1340185162000},"page":"1932-1940","source":"Crossref","is-referenced-by-count":12,"title":["Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal 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