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Interestingly, a significant association has been demonstrated between PD and low levels of vitamin D in the serum, and vitamin D supplement appears to have a beneficial clinical effect on PD. Genetic studies have provided the opportunity to determine which proteins link vitamin D to PD pathology, e.g., <jats:italic>Nurr1<\/jats:italic> gene, toll\u2010like receptor, gene related to lipid disorders, vascular endothelial factor, tyrosine hydroxylase, and angiogenin. Vitamin D also exerts its effects on cancer through nongenomic factors, e.g., bacillus Calmette\u2010Guerin vaccination, interleukin\u201010, Wnt\u03b2\u2010catenin signaling pathways, mitogen\u2010activated protein kinase pathways, and the reduced form of the nicotinamide adenine dinucleotide phosphate. In conclusion, vitamin D might have a beneficial role in PD. Calcitriol is best used for PD because it is the active form of the vitamin D<jats:sub>3<\/jats:sub> metabolite and modulates inflammatory cytokine expression. 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