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Forty Wistar rats were randomly divided into control, A\u03b21\u201342, SIF + A\u03b21\u201342, and SIF groups according to body weight. The rats in the SIF + A\u03b21\u201342 group and SIF group were intragastrically administered SIF suspension in 0.5% CMC\u2010Na for 28 days, whereas the rats in control group and A\u03b21\u201342 group were administered the same volume of 0.5% CMC\u2010Na. On day 14, the rats in the A\u03b21\u201342 group and SIF + A\u03b21\u201342 group were injected with A\u03b21\u201342 into the lateral cerebral ventricle with physiological saline. The rat brains were then sampled, and brain mitochondria were isolated. After this, the mitochondrial membrane potential (MMP) and mitochondrial redox state were measured. The contents of brain nuclear factor E2\u2010related factor (Nrf2) and heme oxygenase\u20101 (HO\u20101) protein in brain tissue were quantitated by Western blot. The results showed that SIF maintained the MMP, elevated the reduced glutathione\/oxidized glutathione (GSH\/GSSG) ratio, and increased glutathione peroxidase (GPx) and manganese superoxide dismutase (MnSOD) protein expression in brain mitochondria. Additionally, SIF reversed the A\u03b21\u201342\u2010induced downregulation of the protein expression of Nrf2 and HO\u20101 in brain tissue. These results indicated that SIF could alleviate the oxidative damage and maintain the redox imbalance in brain mitochondria damaged by A\u03b21\u201342. This might result from regulation of the Nrf2\/HO\u20101 pathway. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23163","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T02:27:30Z","timestamp":1355452050000},"page":"562-567","source":"Crossref","is-referenced-by-count":44,"title":["Soy isoflavone attenuates brain mitochondrial oxidative stress induced by beta\u2010amyloid peptides 1\u201342 injection in lateral cerebral 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