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Within 7 days after acute administration, GDNF (800 ng, i.c.v.) decreased cataleptic immobility but increased depressive\u2010like behavioral traits in both investigated mouse strains and produced anxiolytic effects in ASC mice. The expression of the gene encoding the key enzyme for 5\u2010HT biosynthesis in the brain, tryptophan hydroxylase\u20102 (Tph\u20102), and 5\u2010HT<jats:sub>1A<\/jats:sub>receptor gene in the midbrain as well as 5\u2010HT<jats:sub>2A<\/jats:sub>receptor gene in the frontal cortex were increased in GDNF\u2010treated ASC mice. At the same time, GDNF decreased 5\u2010HT<jats:sub>1A<\/jats:sub>and 5\u2010HT<jats:sub>2A<\/jats:sub>receptor gene expression in the hippocampus of ASC mice. GDNF failed to change Tph2, 5\u2010HT<jats:sub>1A<\/jats:sub>, or 5\u2010HT<jats:sub>2A<\/jats:sub>receptor mRNA levels in CBA mice as well as 5\u2010HT transporter gene expression and 5\u2010HT<jats:sub>1A<\/jats:sub>and 5\u2010HT<jats:sub>2A<\/jats:sub>receptor functional activity in both investigated mouse strains. The results show 1) a GDNF\u2010induced increase in the expression of key genes of the brain 5\u2010HT system, Tph2, 5\u2010HT<jats:sub>1A<\/jats:sub>, and 5\u2010HT<jats:sub>2A<\/jats:sub>receptors, and 2) significant genotype\u2010dependent differences in the 5\u2010HT system response to GDNF treatment. The data suggest that genetically defined cross\u2010talk between neurotrophic factors and the brain 5\u2010HT system underlies the variability in behavioral response to GDNF. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23286","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T14:13:12Z","timestamp":1381241592000},"page":"1628-1638","source":"Crossref","is-referenced-by-count":38,"title":["Effect of glial cell line\u2010derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders"],"prefix":"10.1002","volume":"91","author":[{"given":"Vladimir S.","family":"Naumenko","sequence":"first","affiliation":[{"name":"Department of Behavioral Neurogenomics Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria 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