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The flavonoid baicalein is known to have antibacterial, antiviral, and antiinflammatory activities. In the present study, the neuroprotective effects of baicalein were examined in a murine 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,4\u2010tetrahydropyridine (MPTP) model of PD. Low doses of baicalein improved motor ability and prevented dopaminergic neuron loss caused by MPTP. In addition, microglial and astrocyte activations were reduced in PD mice pretreated with baicalein. Further study of primary astrocytes revealed that baicalein suppressed the 1\u2010methyl\u20104\u2010phenylpyridine\u2010induced nuclear translocation of nuclear factor\u2010\u03baB and reduced the activations of JNK and ERK, suggesting that the neuroprotective effects of baicalein in our PD model were due to attenuated astrocyte activation. The findings of this study indicate that baicalein could be useful for the treatment of PD and other neuroinflammation\u2010related neurodegenerative diseases. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23307","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T09:49:25Z","timestamp":1382953765000},"page":"130-139","source":"Crossref","is-referenced-by-count":103,"title":["Baicalein attenuates astroglial activation in the 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,4\u2010tetrahydropyridine\u2010induced Parkinson's disease model by downregulating the activations of nuclear factor\u2010\u03baB, ERK, and JNK"],"prefix":"10.1002","volume":"92","author":[{"given":"Eunjin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Molecular Inflammation Research Center for Aging Intervention Pusan National University Busan Republic of 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