{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:12:25Z","timestamp":1772777545193,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology","award":["2010-0010580"],"award-info":[{"award-number":["2010-0010580"]}]},{"name":"NRF funded by the Korean government (MEST)","award":["2011-0028790"],"award-info":[{"award-number":["2011-0028790"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Risperidone, an atypical antipsychotic drug, has been discovered to have some beneficial effects beyond its original effectiveness. The present study examines the neuroprotective effects of risperidone against ischemic damage in the rat and gerbil induced by transient focal and global cerebral ischemia, respectively. The results showed that pre\u2010 and posttreatment with 4 mg\/kg risperidone significantly protected against neuronal death from ischemic injury. Many NeuN\u2010immunoreactive neurons and a few F\u2010J B\u2010positive cells were found in the rat cerebral cortex and gerbil hippocampal CA1 region (CA1) in the risperidone\u2010treated ischemia groups compared with those in the vehicle\u2010treated ischemia group. In addition, treatment with risperidone markedly attenuated the activation of microglia in the gerbil CA1. On the other hand, we found that treatment with risperidone significantly maintained the antioxidants levels in the ischemic gerbil CA1. Immunoreactivities of superoxide dismutases 1 and 2, catalase, and glutathione peroxidase were maintained in the stratum pyramidale of the CA1; the antioxidants were very different from those in the vehicle\u2010treated ischemia groups. In brief, our present findings indicate that posttreatment as well as pretreatment with risperidone can protect neurons in the rat cerebral cortex and gerbils CA1 from transient cerebral ischemic injury and that the neuroprotective effect of risperidone may be related to attenuation of microglial activation as well as maintenance of antioxidants. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23360","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T11:11:33Z","timestamp":1391166693000},"page":"795-807","source":"Crossref","is-referenced-by-count":24,"title":["Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke"],"prefix":"10.1002","volume":"92","author":[{"given":"Bing Chun","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Integrative Traditional and Western 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