{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:16:38Z","timestamp":1790367398134,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council of Science and Technology of Mexico","award":["014147"],"award-info":[{"award-number":["014147"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>In humans, exposure to organic solvents (OS) is frequent in work activities or as a recreational inhalant, inducing severe neuropathy (secondary to demyelization of peripheral nerves). We have previously shown that all\u2010trans retinoic acid (ATRA) increases local content of neural growth factor (NGF), improving peripheral neuropathy of diverse origins. In this study, we evaluated the effect of ATRA on OS\u2010induced peripheral neuropathy in experimental mice. Two simultaneous experiments were performed. The first one aimed to evaluate ATRA for the prevention of damage induced by OS, the second to test ATRA as an OS\u2010induced neuropathy treatment. Nociceptive threshold latency and NGF concentration in serum and in peripheral nerves were determined. Morphological changes and evidence of sciatic nerve regeneration were evaluated. Mice exposed to OS developed neuropathy and axonal degeneration. ATRA diminished the effects of OS inhalation on sensorial changes and nerve morphology. Treatment with ATRA reversed sensorial and nerve morphological changes of OS\u2010induced neuropathy, and this was associated with increased contents of NGF. Similar to previous experiences on diabetic and toxic neuropathy, ATRA reduced and partially reversed the peripheral neuropathy caused by OS exposure. These favorable effects apparently are due to local production of NGF induced by neural regeneration in response to the administration of retinoic acid. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23376","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T08:34:24Z","timestamp":1395304464000},"page":"1062-1070","source":"Crossref","is-referenced-by-count":7,"title":["Retinoic acid reduces solvent\u2010induced neuropathy and promotes neural regeneration in mice"],"prefix":"10.1002","volume":"92","author":[{"given":"Guadalupe","family":"Palencia","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Hern\u00e1ndez\u2010Pedro","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Laboratory of Experimental Oncology Instituto Nacional de Cancerologia Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saavedra\u2010Perez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Laboratory of Experimental Oncology Instituto Nacional de Cancerologia Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Pe\u00f1a\u2010Curiel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Laboratory of Experimental Oncology Instituto Nacional de Cancerologia Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Ortiz\u2010Plata","sequence":"additional","affiliation":[{"name":"Experimental Neuropathology Laboratory Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Flores\u2010Estrada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Laboratory of Experimental Oncology Instituto Nacional de Cancerologia Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Sotelo","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Mexico City Mexico"},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Laboratory of Experimental Oncology Instituto Nacional de Cancerologia Mexico City Mexico"},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00247-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815368"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310114"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01467.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e045c"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"1","article-title":"Human solvent exposure. 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