{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:54:24Z","timestamp":1792403664337,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The pituitary appears to be vulnerable to brain trauma, and its dysfunction is a common feature after traumatic brain injury. The role of pituitary growth hormone (GH) in brain repair after injury has been envisaged, but more studies must be performed to understand completely the importance of GH in these processes. Because some of the neuroprotective effects of GH are mediated directly through the GH receptor (GHR), we examined GHR expression in the rat cerebral cortex after sensorimotor cortex ablation. RT\u2010PCR, immunohistochemistry, and double immunofluorescence had been performed to analyze the correlation between GHR expression in the injured cortex and activity of GH cells in the pituitary. Our results showed that the volume of GH\u2010immunopositive cells was reduced at days 2 and 7 postsurgery (dps), and volume density of GH cells was significantly decreased at 14 dps, all compared with appropriate sham controls. At 30 dps all investigated parameters had returned to control level. In the injured cortex, GHR expression was transiently upregulated. Increased GHR immunoreactivity was observed in reactive astrocytes at 7 and particularly at 14 dps. In neuronal cells, an increase of GHR immunoreactivity was seen in neuronal cell bodies and well\u2010defined primary dendrites at 14 and especially at 30 dps. The results presented here suggest that, during recovery from brain injury, changes in activity of pituitary GH cells result in upregulation of GHR that may have a role in neuronal arborization and glial proliferation in the injured cortex. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23408","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T11:57:13Z","timestamp":1400068633000},"page":"1338-1349","source":"Crossref","is-referenced-by-count":6,"title":["Cortical ablation induces time\u2010dependent changes in rat pituitary somatotrophs and upregulates growth hormone receptor expression in the injured cortex"],"prefix":"10.1002","volume":"92","author":[{"given":"Irena","family":"Lavrnja","sequence":"first","affiliation":[{"name":"Department of Neurobiology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Ajdzanovic","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Trifunovic","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Savic","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verica","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Stojiljkovic","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Pekovic","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Institute for Biological Research \u201cSinisa Stankovic,\u201d University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20047"},{"key":"e_1_2_6_3_1","first-page":"13","article-title":"Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle\u2010aged male rats","volume":"42","author":"Ajdzanovic V","year":"2009","journal-title":"Biol Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1078\/0018-442X-00065"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1242"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23958"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)00217-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01895"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2009.05.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199410000-00011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(92)90168-Z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2011.559611"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.02.022"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00588-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874216501206010034"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01724795"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708405"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874216501206010027"},{"key":"e_1_2_6_20_1","first-page":"161","article-title":"Growth hormone: neurocrine and neuroendocrine perspectives","volume":"3","author":"Harvey S","year":"1993","journal-title":"Growth Regul"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03641.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.03.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0751"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1227\/00006123-198109000-00002","article-title":"Pituitary hormone response to head injury","volume":"9","author":"King LR","year":"1981","journal-title":"Neurosurgery"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.11.005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90277-A"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222998"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350340"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63041426.x"},{"key":"e_1_2_6_30_1","first-page":"665","article-title":"Nestin structure and predicted function in cellular cytoskeletal organization","volume":"20","author":"Michalczyk K","year":"2005","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000028223","article-title":"Morphometric and functional changes of the rat pituitary somatotropes and lactotropes after central administration of somatostatin","volume":"57","author":"Milo\u0161evi\u0107 V","year":"1998","journal-title":"Pharmacology"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2298\/ABS1202451M"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.040"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2705"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184752"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2000.0200"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(09)88014-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-21-33"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.05.023"},{"key":"e_1_2_6_40_1","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G","year":"2004"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-6047-z"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:5:1:61"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0049-1"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01757-6"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00051-0"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2000-s623"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00109-9"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490377"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.08.002"},{"key":"e_1_2_6_50_1","volume-title":"Stereological methods 1. Practical methods for biological morphometry","author":"Weibel ER.","year":"1979"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.23408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.23408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:34:39Z","timestamp":1696502079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.23408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/jnr.23408"],"URL":"https:\/\/doi.org\/10.1002\/jnr.23408","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}