{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:10:50Z","timestamp":1785157850668,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a potent vasodilator and regulates cardiovascular homeostasis. Furthermore, H<jats:sub>2<\/jats:sub>S has a crucial role in ischemia\u2212reperfusion injuries, especially of the heart, liver, and kidneys. This study indicates that treatment with hydrogen sulfide is able to restore neurological function after ischemic stroke by promoting angiogenesis. Treatment with H<jats:sub>2<\/jats:sub>S augments angiogenesis in the peri\u2010infarct area, and it significantly improves functional outcomes after 2 weeks in a rat MCAO model. H<jats:sub>2<\/jats:sub>S promotes the phosphorylation of AKT and ERK and increases the expression of vascular endothelial growth factor (VEGF) and angiopoietin\u20101 (Ang\u20101). H<jats:sub>2<\/jats:sub>S\u2010treated rats showed more newly synthesized endothelial cells in the ischemic lesion (2.31\u2010fold, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). H<jats:sub>2<\/jats:sub>S\u2010treated astrocytes increased VEGF and Ang\u20101 expression, and the inhibition of phosphatidylinositide 3\u2010kinase (PI3K)\/AKT signaling by LY294002 significantly reduced H<jats:sub>2<\/jats:sub>S\u2010induced VEGF and Ang\u20101 expression in astrocytes. Finally, H<jats:sub>2<\/jats:sub>S stimulated endothelial cell migration (3.92\u2010fold increase in wound healing assay) and tube formation (3.69\u2010fold increase, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) through PI3K\/AKT signaling. In conclusion, treatment with H<jats:sub>2<\/jats:sub>S promotes angiogenesis and thereby contributes to improvement of functional outcome after cerebral ischemia. Our findings strongly suggest that H<jats:sub>2<\/jats:sub>S may be of value in regenerative recovery after stroke. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23427","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:09:54Z","timestamp":1403024994000},"page":"1520-1528","source":"Crossref","is-referenced-by-count":70,"title":["Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia"],"prefix":"10.1002","volume":"92","author":[{"given":"Hyunduk","family":"Jang","sequence":"first","affiliation":[{"name":"Neuroscience Research Institute in SNUMRC Seoul National University Seoul Republic of Korea"},{"name":"Department of Neurology, Clinical Research Institute Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute in SNUMRC Seoul National 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