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The present study uses an automated behavioral analysis system to assess alterations in rodent behavior in the subacute phase in a preclinical mouse model of TBI, controlled cortical impact (CCI) injury. In the first few weeks following CCI, mice demonstrated normal exploratory behaviors and other typical home\u2010cage behaviors. However, beginning 4 weeks post\u2010injury, CCI mice developed disruptions in sleep\u2013wake patterns, including an increased number of awakenings from sleep. Such impaired sleep maintenance was accompanied by an increased latency to reach peak sleep in CCI mice. These sleep disruptions implicate involvement of the thalamocortical network, the activity of which must be tightly regulated to control sleep maintenance. After injury, there was an increase in reactive microglia in thalamic regions as well as delayed reactive astrocytosis that was evident in the thalamic reticular nucleus, which preceded the development of sleep disruptions. These data suggest that cortical injury may trigger inflammatory responses in deeper neuroanatomical structures, including the thalamic reticular nucleus. Such engagement of the thalamus may perturb the thalamocortical network that regulates sleep\/awake patterns and contribute to sleep disruptions observed in this model as well as those documented in patients with TBI. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23430","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T11:26:46Z","timestamp":1403695606000},"page":"1434-1445","source":"Crossref","is-referenced-by-count":47,"title":["Delayed thalamic astrocytosis and disrupted sleep\u2013wake patterns in a preclinical model of traumatic brain injury"],"prefix":"10.1002","volume":"92","author":[{"given":"Anupam","family":"Hazra","sequence":"first","affiliation":[{"name":"Department of Neuroscience Thomas Jefferson University Philadelphia Pennsylvania"},{"name":"Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Macolino","sequence":"additional","affiliation":[{"name":"Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia Pennsylvania"},{"name":"Department of Neurological Surgery Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie B.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Thomas Jefferson University Philadelphia Pennsylvania"},{"name":"Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia Pennsylvania"},{"name":"Department of Neurological Surgery Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Thomas Jefferson University Philadelphia Pennsylvania"},{"name":"Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053376"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.01.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1883"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23114"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409644102"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2008.06.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.05.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0807-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3607-05.2006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-012-9192-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699059409151024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0943"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051100"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.180"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26855"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"Surveillance for traumatic brain injury\u2010related deaths\u2014United States, 1997\u20132007","volume":"60","author":"Coronado VG","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12098"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2124"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2010.08.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.104"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02160.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1672"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","unstructured":"FaulM XuL WaldMM CoronadoVG.2010. 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