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M\u00c3\u00b8ller og Hustru Chastine MC-kinney M\u00c3\u00b8llers Fond til almene Formaal"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vetenskapsr\u00c3\u00a5det","award":["2006-4268"],"award-info":[{"award-number":["2006-4268"]}]},{"name":"\u00c3\u2026hlen-stiftelsen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>The \u03b3\u2010aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To investigate GABA and its B receptor in PNS development and degeneration, we studied the expression of the GABA<jats:sub>B<\/jats:sub> receptor, GABA, and glutamic acid decarboxylase GAD65\/67 in both development and injury in fetal dissociated dorsal root ganglia (DRG) cell cultures and in the rat sciatic nerve. We found that GABA, GAD65\/67, and the GABA<jats:sub>B<\/jats:sub> receptor were expressed in premyelinating and nonmyelinating Schwann cells throughout development and after injury. A small population of myelinated sensory fibers displayed all of these molecules at the node of Ranvier, indicating a role in axon\u2013glia communication. Functional studies using GABA<jats:sub>B<\/jats:sub> receptor agonists and antagonists were performed in fetal DRG primary cultures to study the function of this receptor during development. The results show that GABA, via its B receptor, is involved in the myelination process but not in Schwann cell proliferation. The data from adult nerves suggest additional roles in axon\u2013glia communication after injury. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23489","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T12:31:10Z","timestamp":1413635470000},"page":"285-295","source":"Crossref","is-referenced-by-count":14,"title":["GABA and its B\u2010receptor are present at the node of <scp>R<\/scp>anvier in a small population of sensory fibers, implicating a role in myelination"],"prefix":"10.1002","volume":"93","author":[{"given":"Mikael","family":"Corell","sequence":"first","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Wicher","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Uppsala University Uppsala Sweden"},{"name":"Department of Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna J.","family":"Radomska","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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