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The purpose of this study was to examine, by brain microdialysis, the effects of fatty acid amide hydrolase (FAAH) inhibition on noradrenergic and \u03b3\u2010aminobutyric acid (GABA)\u2010ergic neurotransmission in the prefrontal cortex (PFC) and basolateral amygdala (BLA) of rats subjected to a 20\u2010min swim stress. Microdialysis started on stress\u2010 and drug\u2010na\u00efve rats that were treated with the FAAH inhibitor URB597 (0.1 or 0.3 mg\/kg) 30 min before undergoing the stress procedure. Dialysate samples were collected every 20 min from the beginning of the experiment. Concentrations of noradrenaline (NA) and GABA were determined by HPLC coupled to electrochemical and fluorescence detection, respectively. We found that neither URB597 treatment nor 20 min of swim stress exposure per se altered NA and GABA extracellular levels in PFC or BLA. Interestingly, rats treated with 0.1 mg\/kg of URB597 followed by 20 min of stress showed significantly higher NA and GABA levels in PFC and BLA. These effects were absent in rats treated with 0.3 mg\/kg URB597, indicating a dose\u2010specific effect. Moreover, we found that the pretreatment with the CB1 receptor antagonist rimonabant blocked the URB597 effects on NA and GABA release in PFC and BLA of animals subjected to forced swimming. The present study might provide an important first step toward understanding the mechanisms through which URB597 modulates stress\u2010induced neuroendocrine secretion and behavioral coping strategies. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23539","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T05:43:53Z","timestamp":1421041433000},"page":"777-787","source":"Crossref","is-referenced-by-count":29,"title":["Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress"],"prefix":"10.1002","volume":"93","author":[{"given":"Gaurav","family":"Bedse","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome 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