{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:27Z","timestamp":1790957547114,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2009-0083538"],"award-info":[{"award-number":["2009-0083538"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A4A01005837"],"award-info":[{"award-number":["NRF-2013R1A1A4A01005837"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the nigrostriatal pathway. The lipophile 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) can cross the blood\u2013brain barrier and is subsequently metabolized into toxic1\u2010methyl\u20104\u2010phenylpyridine (MPP<jats:sup>+<\/jats:sup>), which causes mitochondrial dysfunction and the selective cell death of dopaminergic neurons. The present article reports the neuroprotective effects of silibinin in a murine MPTP model of PD. The flavonoid silibinin is the major active constituent of silymarin, an extract of milk thistle seeds, and is known to have hepatoprotective, anticancer, antioxidative, and neuroprotective effects. In the present study, silibinin effectively attenuated motor deficit and dopaminergic neuronal loss caused by MPTP. Furthermore, in vitro study confirmed that silibinin protects primary cultured neurons against MPP<jats:sup>+<\/jats:sup>\u2010induced cell death and mitochondrial membrane disruption. The findings of the present study indicate that silibinin has neuroprotective effects in MPTP\u2010induced models of PD rather than antioxidative or anti\u2010inflammatory effects and that the neuroprotection afforded might be mediated by the stabilization of mitochondrial membrane potential. Furthermore, these findings suggest that silibinin protects mitochondria in MPTP\u2010induced PD models and that it offers a starting point for the development of treatments that ameliorate the symptoms of PD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23544","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T18:05:31Z","timestamp":1423764331000},"page":"755-765","source":"Crossref","is-referenced-by-count":66,"title":["Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization"],"prefix":"10.1002","volume":"93","author":[{"given":"Yujeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy College of Pharmacy and Research Institute for Drug Development Longevity Life Science and Technology Institutes, Pusan National University Geumjeong\u2010gu Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Ra","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy and Research Institute for Drug Development Longevity Life Science and Technology Institutes, Pusan National University Geumjeong\u2010gu Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jeong","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy and Research Institute for Drug Development Longevity Life Science and Technology Institutes, Pusan National University Geumjeong\u2010gu Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy and Research Institute for Drug Development Longevity Life Science and Technology Institutes, Pusan National University Geumjeong\u2010gu Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1868"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.038"},{"key":"e_1_2_6_5_1","first-page":"357805","article-title":"Glial\u2010mediated inflammation underlying parkinsonism","volume":"2013","author":"Barcia C.","year":"2013","journal-title":"Scientifica (Cairo)"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00108-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00083-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23061"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.034"},{"issue":"5","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1212\/WNL.54.5.21A","article-title":"Prevalence of Parkinson's disease in Europe: a collaborative study of population\u2010based cohorts. 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