{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:38:22Z","timestamp":1788871102006,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK090370"],"award-info":[{"award-number":["DK090370"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006280","name":"Urology Care Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    Despite nerve\u2010sparing radical prostatectomy, nerve damage and erectile dysfunction (ED) prevail, and preventing neurodegeneration is of great importance. Neurotrophic factors and neurite outgrowth were characterized in major pelvic ganglia (MPG) following bilateral cavernous nerve injury (BCNI). Young male Sprague\u2010Dawley rats underwent sham or BCNI surgery, and the intracavernosal pressure to mean arterial pressure ratio was measured 2, 7, 14, 21, 30, and 60 days following injury (n\u2009=\u20098\/group). MPG gene expression (qPCR) and Western blot were performed for glial cell line\u2010derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurturin, neurotrophin (NT)\u22123, NT4, brain\u2010derived neurotrophic factor (BDNF), vascular endothelial growth factor, and activating transcription factor 3 (ATF3). Additional rats were injured, and MPGs were removed 24 hr, 48 hr, 3 days, and 7 days following BCNI (n\u2009=\u20093\/group). MPGs were cultured in Matrigel, and neurite outgrowth was measured. Erections were impaired early and improved by 60 days in BCNI rats. GDNF, NGF, BDNF, and ATF3 gene expression was significantly increased and NT3 was decreased in MPGs following BCNI (48 hr to 21 days,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). GDNF and NGF protein levels were elevated in 48\u2010hr BCNI rats. MPG neurite outgrowth from 24\u2010hr and 48\u2010hr BCNI was higher than sham (658\u2009\u00b1\u200919 \u03bcm, 607\u2009\u00b1\u200924 \u03bcm, 393\u2009\u00b1\u200923 \u03bcm, respectively,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Further studies examining the roles of neurotrophic factors in modulating signaling pathways may provide therapeutic avenues for neurogenically mediated ED. \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jnr.23553","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:48:27Z","timestamp":1421628507000},"page":"954-963","source":"Crossref","is-referenced-by-count":18,"title":["Temporal changes in neurotrophic factors and neurite outgrowth in the major pelvic ganglion following cavernous nerve injury"],"prefix":"10.1002","volume":"93","author":[{"given":"Johanna L.","family":"Hannan","sequence":"first","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Albersen","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Urology Department of Development and Regeneration University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard L.","family":"Stopak","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopu","family":"Liu","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Burnett","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Hoke","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinity J.","family":"Bivalacqua","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1523\/JNEUROSCI.18-01-00328.1998","article-title":"Comparison of neurite outgrowth induced by intact and injured sciatic nerves: a confocal and functional analysis","volume":"18","author":"Aguis E","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66302-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00291.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7221-2-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.10.043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12030"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.11.053"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0022-5347(17)37825-4","article-title":"Nerve growth factor, nerve grafts, and amniotic membrane grafts restore erectile function in rats","volume":"146","author":"Burger JK","year":"1991","journal-title":"J Urol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10705.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9359-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05155.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.104"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12522"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01000-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04373.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01942.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302990"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.132"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00053"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000273"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04439.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00292.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08647.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.051"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-41"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2626"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.227"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5313-06.2007"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1523\/JNEUROSCI.17-02-00646.1997","article-title":"A transcription\u2010dependent switch controls competence of adult neurons for distinct modes of axon growth","volume":"15","author":"Smith DS","year":"1997","journal-title":"J Neurosci."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/382080a0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0814"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91341-B"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90157-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12570"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1727"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.23553","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.23553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:43:24Z","timestamp":1696326204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.23553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,19]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/jnr.23553"],"URL":"https:\/\/doi.org\/10.1002\/jnr.23553","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,19]]}}}