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From the study to find novel antiparkinsonism drugs that can inhibit MAO\u2010B activity, neuronal loss, and behavioral deficits in the mouse model of PD, we identified that 1\u2010[2\u2010(4\u2010benzyloxyphenoxy)ethyl]imidazole (BPEI) or safinamide strongly and selectively inhibited MAO\u2010B activities in a dose\u2010dependent manner (IC<jats:sub>50<\/jats:sub> of BPEI and safinamide for MAO\u2010B were 0.016 and 0.0021 \u00b5M and for MAO\u2010A were 70.0 and 370 \u00b5M, respectively). In ex vivo studies after an administration (30 mg\/kg, i.p.) of BPEI or safinamide to normal mice, the MAO\u2010B activity in the brain was reduced by up to 90.6% or 82.4% at 1.0 hr. BPEI (20 mg\/kg, i.p.) or safinamide (20 mg\/kg, i.p.) significantly reversed the behavioral impairments, dopamine levels in the striatum, and neuronal loss in the substantia nigra of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010treated mice compared with the MPTP\u2010alone\u2010treated group. In the 6\u2010hydroxydopamine\u2010induced PD rat model, behavioral improvement by levodopa sparing activity was observed in the BPEI\u2010 or safinamide\u2010treated (20 mg\/kg, i.p.) rats. Moreover, BPEI revealed additional curative activities for nonmotor symptoms of PD such as pain, anxiety, epilepsy, and depression in rodent disease models. Therefore, BPEI has broad therapeutic potential for treating motor symptoms via strong and selective inhibitory effects on MAO\u2010B, with additional benefits for comorbid symptoms in PD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23577","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T05:15:51Z","timestamp":1424841351000},"page":"1267-1278","source":"Crossref","is-referenced-by-count":17,"title":["1\u2010[2\u2010(4\u2010Benzyloxyphenoxy)Ethyl]Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease"],"prefix":"10.1002","volume":"93","author":[{"given":"Jin Yong","family":"Chung","sequence":"first","affiliation":[{"name":"Drug Discovery Center SK Biopharmaceuticals Ltd. 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Dae Jeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Lim","sequence":"additional","affiliation":[{"name":"Drug Discovery Center SK Biopharmaceuticals Ltd. Dae Jeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Drug Discovery Center SK Biopharmaceuticals Ltd. 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