{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:03:54Z","timestamp":1772647434001,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81271470"],"award-info":[{"award-number":["81271470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31300840"],"award-info":[{"award-number":["31300840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["4144092"],"award-info":[{"award-number":["4144092"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Functional neuroimaging studies suggest that abnormal brain functional connectivity may be the neural underpinning of addiction to illicit drugs and of relapse after successful cessation therapy. Aberrant brain networks have been demonstrated in addicted patients and in newly abstinent addicts. However, it is not known whether abnormal brain connectivity patterns persist after prolonged abstinence. In this cross\u2010sectional study, whole\u2010brain resting\u2010state functional magnetic resonance images (8 min) were collected from 30 heroin\u2010addicted individuals after a long period of abstinence (more than 3 years) and from 30 healthy controls. We first examined the group differences in the resting\u2010state functional connectivity of the nucleus accumbens (NAc), a brain region implicated in relapse\u2010related processes, including craving and reactivity to stress following acute and protracted withdrawal from heroin. We then examined the relation between the duration of abstinence and the altered NAc functional connectivity in the heroin group. We found that, compared with controls, heroin\u2010dependent participants exhibited significantly greater functional connectivity between the right ventromedial prefrontal cortex and the NAc and weaker functional connectivity between the NAc and the left putamen, left precuneus, and supplementary motor area. However, with longer abstinence time, the strength of NAc functional connectivity with the left putamen increased. These results indicate that dysfunction of the NAc functional network is still present in long\u2010term\u2010abstinent heroin\u2010dependent individuals. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23608","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T13:06:05Z","timestamp":1439816765000},"page":"1693-1702","source":"Crossref","is-referenced-by-count":35,"title":["Abnormal resting\u2010state functional connectivity of the nucleus accumbens in multi\u2010year abstinent heroin addicts"],"prefix":"10.1002","volume":"93","author":[{"given":"Feng","family":"Zou","sequence":"first","affiliation":[{"name":"Cognitive and Mental Health Research Center, Beijing Institute of Basic Medical Science Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Military General Hospital Beijing 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