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Some studies show clear impairments, whereas others report no deficiency. The present study uses hippocampal slices from 3\u2010, 10\u2010, and 15\u2010month\u2010old wild\u2010type (WT) and Tg2576 mice to evaluate synaptic function in each group, including experiments to investigate basal synaptic transmission, short\u2010 and long\u2010term plasticity by inducing paired\u2010pulse facilitation, and both early and late LTP. We show that synaptic function remains intact in hippocampal slices from Tg2576 mice at 3 months of age. However, both early and late LTP decline progressively during aging in these mice. This deterioration of synaptic plasticity starts affecting early LTP, ultimately leading to the abolishment of both forms of LTP in 15\u2010month\u2010old animals. In comparison, WT littermates display normal synaptic parameters during aging. Additional pharmacological investigation into the involvement of NMDA receptors and L\u2010type voltage\u2010gated calcium channels in LTP suggests a distinct mechanism of induction among age groups, demonstrating that both early and late LTP are differentially affected by these channels in Tg2576 mice during aging. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23701","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T13:42:50Z","timestamp":1449063770000},"page":"266-281","source":"Crossref","is-referenced-by-count":6,"title":["Age\u2010related synaptic dysfunction in Tg2576 mice starts as a failure in early long\u2010term potentiation which develops into a full abolishment of late long\u2010term potentiation"],"prefix":"10.1002","volume":"94","author":[{"given":"Diego","family":"Fern\u00e1ndez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Deparment of CNS Diseases Research Boehringer Ingelheim Pharma GmbH &amp; Co. 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