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At the same time, a deviation from optimal conditions often attenuates the performance of biological functions, and such restricted performance could be considered as individual fatigue, including physical and mental fatigue. The present study seeks to develop an animal model of chronic or subacute fatigue in which the recovery time is extended through the gradual disruption of homeostasis. We show that repeated short\u2010term rest periods with certain lengths of sleep during continuous fatigue loading extend recovery from spontaneous nighttime activity but not physical performance in comparison with a continuous fatigue\u2010loading procedure. Furthermore, the immobility time in a forced swimming test was extended by repeated short\u2010term rests. These results suggest that repeated short\u2010term rest with certain lengths of sleep during continuous fatigue loading is able to extend the recovery from mental fatigue but not from physical fatigue and that this effect might occur via the disruption of a homeostatic mechanism that is involved in restoring the optimal internal environment. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23718","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T12:51:22Z","timestamp":1455195082000},"page":"424-429","source":"Crossref","is-referenced-by-count":8,"title":["Extension of recovery time from fatigue by repeated rest with short\u2010term sleep during continuous fatigue load: Development of chronic fatigue model"],"prefix":"10.1002","volume":"94","author":[{"given":"Akinori","family":"Kanzaki","sequence":"first","affiliation":[{"name":"Division of Biofunction Dynamics Imaging RIKEN Center for Life Science Technologies Chuo\u2010ku Kobe 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