{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:18:32Z","timestamp":1791263912095,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,5]],"date-time":"2016-06-05T00:00:00Z","timestamp":1465084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Korean National Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Science Research Program of the National Research Foundation","award":["2009-0083538"],"award-info":[{"award-number":["2009-0083538"]}]},{"name":"Basic Science Research Program of the National Research Foundation","award":["NRF-2013R1A1A4A01005837"],"award-info":[{"award-number":["NRF-2013R1A1A4A01005837"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (SN). Although the causes of PD are not understood, evidence suggests that oxidative stress, mitochondrial dysfunction, and inflammation are associated with its pathogenesis. Morin (3,5,7,2\u2032,4\u2032\u2010pentahydroxyflavone) is a flavonol found in wine and many herbs and fruits. Previous studies have suggested that morin prevents oxidative damage and inflammation and ameliorates mitochondrial dysfunction. The present study describes the neuroprotective effects of morin in a 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010induced mouse model of PD, and we report the results of our investigation into its neuroprotective mechanism in primary neurons and astrocytes. In the mouse model, morin pretreatment ameliorated motor dysfunction, protected against dopaminergic neuronal losses in SN and striatum, and alleviated MPTP\u2010induced astrocyte activation. In vitro studies revealed that morin protected primary cultured neurons against 1\u2010methyl\u20104\u2010phenylpyridine (MPP<jats:sup>+<\/jats:sup>)\u2010mediated reactive oxygen species production and mitochondrial membrane potential (MMP) disruption. In addition, morin effectively reduced MPP<jats:sup>+<\/jats:sup>\u2010induced astroglial activation and nuclear translocation of nuclear factor\u2010\u03baB in primary cultured astrocytes. These results indicate that morin acts via multiple neuroprotective mechanisms in our mouse model and suggest that morin be viewed as a potential treatment and preventative for PD. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23764","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T04:42:46Z","timestamp":1465188166000},"page":"865-878","source":"Crossref","is-referenced-by-count":75,"title":["Neuroprotective and anti\u2010inflammatory effects of morin in a murine model of Parkinson's disease"],"prefix":"10.1002","volume":"94","author":[{"given":"Kyung Moon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention Pusan National University Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy 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