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This study investigates whether type 1 galanin receptor (GAL1) in the brain mediates the ameliorative effect of galanin on insulin resistance in skeletal muscles of type 2 diabetic rats. Rats were intracerebroventricularly (i.c.v.) injected with galanin(1\u201313)\u2010bradykinin(2\u20139) amide (M617), a GAL1 agonist, and\/or Akti\u20101\/2, an Akt inhibitor, via caudal veins once per day for 10 days. Insulin resistance in muscle tissues was evaluated by glucose tolerance and 2\u2010[N\u2010(7\u2010nitrobenz\u20102\u2010oxa\u20101,3\u2010diazol\u20104\u2010yl)amino]\u20102\u2010deoxyglucose (2\u2010NBDG) tests, peroxisome proliferator\u2010activated receptor\u2010\u03b3 (PPAR\u03b3), glucose transporter 4 (GLUT4) mRNA expression levels, Akt phosphorylation, and GLUT4 and vesicle\u2010associated membrane protein 2 (VAMP2) concentration at plasma membranes in muscle cells. The results show that i.c.v. treatment with M617 increased glucose tolerance, 2\u2010NBDG uptake, PPAR\u03b3 levels, Akt phosphorylation, GLUT4 protein, and GLUT4 mRNA expression levels as well as GLUT4 and VAMP2 concentration at plasma membranes. All increases may be blocked by pretreatment with Akti\u20101\/2. These results suggest that activated central GAL1 may trigger the Akt signaling pathway to alleviate insulin resistance in muscle cells. Therefore, the impact of galanin on insulin resistance is mediated mainly by GAL1 in the brain, and the GAL1 agonist may be taken as a potential antidiabetic agent for treatment of type 2 diabetes mellitus. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23775","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T16:42:26Z","timestamp":1468428146000},"page":"947-955","source":"Crossref","is-referenced-by-count":9,"title":["Activated central galanin type 1 receptor alleviated insulin resistance in diabetic rat muscle"],"prefix":"10.1002","volume":"94","author":[{"given":"Le","family":"Bu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Shanghai 10th People's Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xusheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of General Surgery 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