{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:28:13Z","timestamp":1791930493585,"version":"4.3.4"},"reference-count":158,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:00:00Z","timestamp":1468281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["#11\/RFP\/NES\/3175"],"award-info":[{"award-number":["#11\/RFP\/NES\/3175"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["10\/IN.1\/B2976"],"award-info":[{"award-number":["10\/IN.1\/B2976"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>A wealth of research over the past 2 decades has expanded our understanding of the impact of early\u2010life adversity on physiological function and, consequently, health and wellbeing in later life. Early\u2010life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical maltreatment, an increasing number of studies have been published over the past few years examining the effect of childhood psychological stress and trauma on the development of various types of chronic pain conditions. We review the clinical and preclinical data examining the link among early\u2010life psychological stress, altered nociceptive behavior, and chronic pain in later life. Evidence supporting a role for certain key neurobiological substrates, including the hypothalamic\u2010pituitary\u2010adrenal axis; monoaminergic, opioidergic, endocannabinoid and immune systems; and epigenetic mechanisms in the association between early\u2010life psychological stress and chronic pain, is provided. Greater understanding of the impact of early\u2010life stress may inform the development of personalized treatments for chronic pain in later life and strategies to prevent its onset in susceptible individuals. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23802","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T11:05:17Z","timestamp":1468321517000},"page":"1257-1270","source":"Crossref","is-referenced-by-count":242,"title":["Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms"],"prefix":"10.1002","volume":"95","author":[{"given":"Nikita N.","family":"Burke","sequence":"first","affiliation":[{"name":"Physiology, School of Medicine, National University of Ireland Galway Ireland"},{"name":"Centre for Pain Research and Galway Neuroscience Centre, NCBES, National University of Ireland Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Finn","sequence":"additional","affiliation":[{"name":"Centre for Pain Research and Galway Neuroscience Centre, NCBES, National University of Ireland Galway Ireland"},{"name":"Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Centre for Pain Research and Galway Neuroscience Centre, NCBES, National University of Ireland Galway Ireland"},{"name":"Psychology, National University of Ireland Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Roche","sequence":"additional","affiliation":[{"name":"Physiology, School of Medicine, National University of Ireland Galway Ireland"},{"name":"Centre for Pain Research and Galway Neuroscience Centre, NCBES, National University of Ireland Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.12.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00698.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.05.056"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.02.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.024174"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3180db2949"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371506000404"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90191-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(19990901)33:3<181::AID-SYN3>3.0.CO;2-R"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.10.016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22267"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.05.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23768"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.04.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01084-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01892.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)13:1<51::AID-ART8>3.0.CO;2-Q"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00409"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.11.022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.054346"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00929.2014"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.055"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.09.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12217"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2015.10.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00240.2001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00090-5"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MEBR.0000027412.19664.b3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000149795.08746.31"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03979.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9304-z"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(97)00149-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890500404634"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i1.13"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000149801.46864.39"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/76061"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.08.013"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1701"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/107385840100700309"},{"key":"e_1_2_9_46_1","article-title":"High times for painful blues: the endocannabinoid system in pain\u2010depression comorbidity","volume":"19","author":"Fitzgibbon M","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.04.007"},{"key":"e_1_2_9_48_1","first-page":"18","article-title":"Broken or maladaptive?","volume":"11","author":"Ganguly P","year":"2015","journal-title":"Altered trajectories in neuroinflammation and behavior after early life adversity. Dev Cogn Neurosci"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.003"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.021"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.10.020"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.10.053"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073926"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000292"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000089"},{"key":"e_1_2_9_56_1","first-page":"107","article-title":"Interactions of early adversity with stress\u2010related gene polymorphisms impact regional brain structure in females","volume":"112","author":"Gupta A","year":"2015","journal-title":"Brain Struct Funct"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328353d70a"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009020914358"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.03.008"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144327"},{"key":"e_1_2_9_61_1","first-page":"395","article-title":"Opioids and opioid receptors mediating antinociception at various levels of the neuraxis","volume":"39","author":"Herz A","year":"1990","journal-title":"Physiol Bohemoslovaca"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6199"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13260.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj080479"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.07.009"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2015.12.003"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.06.012"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.07.039"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.019"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.06.003"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.003"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00485-3"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90041-9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3275"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2014_289"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2010.02.001"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00608.2005"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.06.012"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.03.013"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707165"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.04.002"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.039"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-87"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.04.013"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/140832"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12175"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab3376"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00073"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015906778019527"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-010-9205-z"},{"key":"e_1_2_9_92_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/FBP.0000000000000068","article-title":"Consequences of early life stress on the expression of endocannabinoid\u2010related genes in the rat brain","volume":"25","author":"Marco EM","year":"2014","journal-title":"Behav Pharmacol"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.01.015"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02599.x"},{"key":"e_1_2_9_95_1","first-page":"2305","article-title":"Associations between adverse events in childhood and chronic widespread pain in adulthood: are they explained by differential recall?","volume":"28","author":"McBeth J","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9333-5"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.01.002"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.05.003"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12675"},{"key":"e_1_2_9_100_1","first-page":"139","article-title":"Comparison of acceptance and distraction strategies in coping with experimentally induced pain","volume":"8","author":"Moore H","year":"2015","journal-title":"J Pain Res"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2011.602146"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20694"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00298.2009"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00353.2011"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.11.012"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01065.x"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.026"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2010-9"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00385.2010"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2014_302"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.022"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.105.1.215"},{"key":"e_1_2_9_113_1","first-page":"2109","article-title":"Childhood adversities and laboratory pain perception","volume":"11","author":"Pieritz K","year":"2015","journal-title":"Neuropsychiatric Dis Treat"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00515-9"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(03)00043-X"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12472"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.012"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00400.2006"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.054"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.11.044"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s3511"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90010-G"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-010-9097-6"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22361"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90020-5"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)00057-5"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2096-0"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12414"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.77"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-015-9712-5"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.066"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00468-5"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.672"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20537"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.06.042"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00351-X"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12260"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0554-z"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01906.x"},{"key":"e_1_2_9_140_1","first-page":"215","article-title":"Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat","volume":"31","author":"Tjong YW","year":"2010","journal-title":"Neuroendocrinol Lett"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01697.x"},{"key":"e_1_2_9_142_1","first-page":"68","article-title":"A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing","volume":"3","author":"Tottenham N","year":"2009","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90124-9"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2011.07.005"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.03.055"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws371"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-005-0021-z"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1469"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71505-6"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.05.015"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.01.034"},{"key":"e_1_2_9_152_1","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1523\/JNEUROSCI.23-20-07719.2003","article-title":"Developmental learning in a pain\u2010related system: evidence for a cross\u2010modality mechanism","volume":"23","author":"Waldenstrom A","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.08.004"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.10.002"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00186-7"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1276"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3652-05.2005"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.07.001"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018820315549"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.23802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.23802","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.23802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T19:26:32Z","timestamp":1694460392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.23802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,12]]},"references-count":158,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/jnr.23802"],"URL":"https:\/\/doi.org\/10.1002\/jnr.23802","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,12]]}}}