{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:07:22Z","timestamp":1791266842287,"version":"4.1.0"},"reference-count":155,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Pituitary adenylate cyclase\u2013activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are neuropeptides with wide, complementary, and overlapping distributions in the central and peripheral nervous systems, where they exert important regulatory roles in many physiological processes. VIP and PACAP display a large range of biological cellular targets and functions in the adult nervous system including regulation of neurotransmission and neuroendocrine secretion and neuroprotective and neuroimmune responses. As the main focus of the present review, VIP and PACAP also have been long implicated in nervous system development and maturation through their interaction with the seven transmembrane domain G protein\u2013coupled receptors, PAC1, VPAC1, and VPAC2, initiating multiple signaling pathways. Compared with PAC1, which solely binds PACAP with very high affinity, VPACs exhibit high affinities for both VIP and PACAP but differ from each other because of their pharmacological profile for both natural accessory peptides and synthetic or chimeric molecules, with agonistic and antagonistic properties. Complementary to initial pharmacological studies, transgenic animals lacking these neuropeptides or their receptors have been used to further characterize the neuroanatomical, electrophysiological, and behavioral roles of PACAP and VIP in the developing central nervous system. In this review, we recapitulate the critical steps and processes guiding\/driving neurodevelopment in vertebrates and superimposing the potential contribution of PACAP and VIP receptors on the given timeline. We also describe how alterations in VIP\/PACAP signaling may contribute to both (neuro)developmental and adult pathologies and suggest that tuning of VIP\/PACAP signaling in a spatiotemporal manner may represent a novel avenue for preventive therapies of neurological and psychiatric disorders. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23915","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T15:56:06Z","timestamp":1474905366000},"page":"1472-1487","source":"Crossref","is-referenced-by-count":18,"title":["Neuropeptides shaping the central nervous system development: Spatiotemporal actions of VIP and PACAP through complementary signaling pathways"],"prefix":"10.1002","volume":"94","author":[{"given":"Tando","family":"Maduna","sequence":"first","affiliation":[{"name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives, Centre National de la Recherche Scientifique UPR3212 Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lelievre","sequence":"additional","affiliation":[{"name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives, Centre National de la Recherche Scientifique UPR3212 Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3848-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1419"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101600509"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12405"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2054"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5337.477"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490250316"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118672"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb46155.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(03)00022-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006864"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.02.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3065-04.2004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03138.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-63"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200629200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00268.2004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01676.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.052514"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063848"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(91)90184-I"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.189"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2097"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1548fje"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10098"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087420"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.11.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.031"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2899-04.2005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30213"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.05.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.06.022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22489"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.05.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.02.006"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.10.033"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-9003-0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04112.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126409"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-1-272"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00777-8"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07884.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117555"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07883.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00693.x"},{"key":"e_1_2_9_50_1","first-page":"647","article-title":"Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo","volume":"10","author":"Hammerschmidt M","year":"1996","journal-title":"Dev Biol"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04883.2001"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01871.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001982"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2463"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20090053"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118391"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00155-4"},{"key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/JMN:31:03:185","article-title":"Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistry","volume":"31","author":"Hill JM","year":"2007","journal-title":"J Mol Neurosci"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.06.004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111412200"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1411"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050724"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01124.2015"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1435-9"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150543"},{"key":"e_1_2_9_66_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4142\/jvs.2005.6.1.1","article-title":"Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta","volume":"6","author":"Koh P\u2010O","year":"2005","journal-title":"J Vet Sci"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.04.026"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(99)80077-3"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27597"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-11-03849.2001"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3544"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.04.024"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.10.031"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.03.002"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.2.605"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.08.005"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11181.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.05.015"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200311140-00017"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.85.3.890"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320040403"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-02-00585.1984"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80036-1"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440040205"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)00168-2"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4515-09.2010"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328342568a"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.966"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2015.05.015"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1025044"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.06.002"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2005.10.003"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044691"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09244.2002"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.07.012"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-201007000-00008"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80953-4"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(94)90111-2"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22682"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.08.028"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.03.028"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490390402"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.11.2419"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22193"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43824"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795589409"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.02.010"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.035"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1317.071"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346621"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09856"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1389"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09611"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20853"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:30:3:329"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.6.619"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(98)00086-8"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.014"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.01.017"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2015.08.006"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00294-0"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.2.917"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.003"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/83936"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.04.003"},{"key":"e_1_2_9_126_1","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.2001.281.3.G718","article-title":"Identification of a VIP\u2010specific receptor in guinea pig tenia coli","volume":"281","author":"Teng BQ","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0302"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12198"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3553-12.2012"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2010.544345"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.21.4822"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09884"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1189"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8055-2"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001370"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00177-2"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.06.008"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.07.008"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.203.233"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20419"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338068"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.11.014"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb17491.x"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00015-6"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9602"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1317.089"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21065"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00171-9"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1317.091"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1062-12.2013"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.184"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2002.02018.x"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00108-6"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00138.2006"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70052165.x"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200001000-00012"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.23915","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.23915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T15:13:14Z","timestamp":1694617994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.23915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":155,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/jnr.23915"],"URL":"https:\/\/doi.org\/10.1002\/jnr.23915","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}