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Additionally, dysfunction in gamma\u2010aminobutyric acid, Reelin, and fragile X mental retardation protein (FMRP)\u2013metabotropic glutamate receptor 5 signaling systems has also been demonstrated in these two disorders. In the current report, we have characterized the developmental profiles of selected markers for these systems in cerebella of mice born to pregnant mice infected with human influenza (H1N1) virus on embryonic day 16 or sham\u2010infected controls using SDS\u2010PAGE and Western blotting techniques and evaluated the presence of abnormalities in the above\u2010mentioned markers during brain development. The cerebellum was selected in light of emerging evidence that it plays roles in learning, memory, and emotional processing\u2014all of which are disrupted in autism and schizophrenia. We identified unique patterns of gene and protein expression at birth (postnatal day 0 [P0]), childhood (P14), adolescence (P35), and young adulthood (P56) in both exposed and control mouse progeny. We also identified significant differences in protein expression for FMRP, very\u2010low\u2010density lipoprotein receptor, and glutamic acid decarboxylase 65 and 67 kDa proteins at specific postnatal time points in cerebella of the offspring of exposed mice. Our results provide evidence of disrupted FMRP, glutamatergic, and Reelin signaling in the exposed mouse offspring that explains the multiple brain abnormalities observed in this animal model. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23949","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:16:05Z","timestamp":1476407765000},"page":"1110-1122","source":"Crossref","is-referenced-by-count":13,"title":["The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum"],"prefix":"10.1002","volume":"95","author":[{"given":"S. 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