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Here we discuss genetic aberrations known as copy number variants (CNVs), which fall in the latter category and are associated with a high risk for SZ and other neuropsychiatric disorders. We briefly review recurrent CNVs associated with SZ, and then highlight one CNV in particular, a recurrent 1.6\u2010Mb deletion on chromosome 3q29, which is estimated to confer a 40\u2010fold increased risk for SZ. Additionally, we describe the use of genetic mouse models, behavioral tools, and patient\u2010derived induced pluripotent stem cells as a means to study CNVs in the hope of gaining mechanistic insight into their respective disorders. Taken together, the genomic data connecting CNVs with a multitude of human neuropsychiatric disease, our current technical ability to model such chromosomal anomalies in mouse, and the existence of precise behavioral measures of endophenotypes argue that the time is ripe for systematic dissection of the genetic mechanisms underlying such disease. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23970","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T14:15:13Z","timestamp":1478614513000},"page":"1144-1160","source":"Crossref","is-referenced-by-count":34,"title":["Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders"],"prefix":"10.1002","volume":"95","author":[{"given":"Timothy P.","family":"Rutkowski","sequence":"first","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine Atlanta 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