{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T19:19:17Z","timestamp":1771701557755,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["26290022"],"award-info":[{"award-number":["26290022"]}]},{"name":"JSPS KAKENHI","award":["15K16321"],"award-info":[{"award-number":["15K16321"]}]},{"name":"JSPS KAKENHI","award":["25460109"],"award-info":[{"award-number":["25460109"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra projecting to the striatum. It has been estimated that approximately 80% of the striatal dopamine and 50% of nigral dopaminergic neurons are lost before the onset of typical motor symptoms, indicating that early diagnosis of PD using noninvasive imaging is feasible. Fluorine\u201019 (<jats:sup>19<\/jats:sup>F) magnetic resonance imaging (MRI) represents a highly sensitive, easily available, low\u2010background, and cost\u2010effective approach to evaluate dopaminergic function using non\u2010radioactive fluorine\u2010containing dopaminergic agents. The aim of this study was to find a potent <jats:sup>19<\/jats:sup>F MRI probe to evaluate dopaminergic presynaptic function in the striatum. To select candidates for <jats:sup>19<\/jats:sup>F MRI probes, we investigated the following eight non\u2010radioactive fluorine\u2010containing dopaminergic agents: fluorodopa (F\u2010DOPA), F\u2010tyrosine, haloperidol, GBR13069 duhydrochloride, GBR12909 duhydrochloride, 3\u2010bis\u2010(4\u2010fluorophenyl) methoxytropane hydrochloride, flupenthixol, and fenfluramine. In <jats:sup>19<\/jats:sup>F nuclear magnetic resonance measurements, F\u2010tyrosine and F\u2010DOPA displayed a relatively higher signal\u2010to\u2010noise ratio value in brain homogenates than in others. F\u2010DOPA, but not F\u2010tyrosine, induced the rotational behavior in a 6\u2010hydroxydopamine (6\u2010OHDA)\u2010induced hemiparkinsonian rat model. In addition, a significantly high amount of F\u2010DOPA accumulated in the ipsilateral striatum of hemiparkinsonian rats after the injection. We performed <jats:sup>19<\/jats:sup>F MRI in PC12 cells and isolated rat brain using a 7T MR scanner. Our findings suggest that F\u2010DOPA is a promising <jats:sup>19<\/jats:sup>F MRI probe for evaluating dopaminergic presynaptic function in the striatum of hemiparkinsonian rats. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23983","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T15:32:47Z","timestamp":1477668767000},"page":"1485-1494","source":"Crossref","is-referenced-by-count":6,"title":["Fluorodopa is a Promising Fluorine\u201019 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of <scp>P<\/scp>arkinson's Disease"],"prefix":"10.1002","volume":"95","author":[{"given":"Daijiro","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Molecular Neuroscience Research Center Shiga University of Medical Science Seta Tsukinowa\u2010cho Otsu 520\u20102192 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