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Electroencephalographic spectral power as well as amplitudes and latencies of mismatch negativity (MMN), P300, and P600 components were evaluated among 19 male heroin addicts and 19 healthy nonsmoker subjects using a paradigm consisting of three subparadigms, namely (1) digit span Wechsler test, (2) auditory oddball, and (3) visual cue\u2010reactivity oddball paradigms. Task 1 provided auditory P300 and P600 in association with working memory. Task 2 provided auditory P300 as well as small and large deviant MMN event\u2010related potential (ERPs). Finally, task 3 provided visual cue\u2010reactivity P300. Results show that beta power was higher among heroin addicts while delta, theta, and alpha powers were decreased compared with healthy subjects. ERP analysis confirmed the decline of brain\u2010evoked potential amplitudes when compared with healthy subjects, thus indicating a broad neurobiological vulnerability of preattentive and attentional processing including attentional deficits and compromise of discrimination abilities. The prolonged latency of ERPs reflects poor cognitive capacity in the engagement of attention and memory resources. On the other hand, an increase of attention towards the heroin\u2010related stimuli could be concluded from the increase of P300 in the cue\u2010reactivity condition among heroin addicts. Findings suggest that applying this paradigm in addiction studies benefits comprehensive evaluation of neuroelectrophysiological activity among addicts, which can promote a better understanding of drugs' effects on the brain as well as define new neuroelectrophysiological characteristics of addiction properties. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.23988","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T14:17:26Z","timestamp":1478614646000},"page":"1633-1646","source":"Crossref","is-referenced-by-count":27,"title":["Investigation of brain electrophysiological properties among heroin addicts: Quantitative EEG and event\u2010related potentials"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-0922","authenticated-orcid":false,"given":"Farid","family":"Motlagh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering University of 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