{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:42:55Z","timestamp":1761597775594,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004330","name":"The Smoking Research Foundation","doi-asserted-by":"crossref","award":["H28-75"],"award-info":[{"award-number":["H28-75"]}],"id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["26670036","16H04673","16K15204"],"award-info":[{"award-number":["26670036","16H04673","16K15204"]}]},{"name":"MEXT, Japan","award":["H24-I02"],"award-info":[{"award-number":["H24-I02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Intracerebral hemorrhage (ICH) is associated with diverse sets of neurological symptoms and prognosis, depending on the site of bleeding. Relative rate of hemorrhage occurring in the cerebral cortex (lobar hemorrhage) has been increasing, but there is no report on effective pharmacotherapeutic approaches for cortical hemorrhage either in preclinical or clinical studies. The present study aimed to establish an experimental model of cortical hemorrhage in mice for evaluation of effects of therapeutic drug candidates. Type VII collagenase at 0.015 U, injected into the parietal cortex, induced hemorrhage expanding into the whole layer of the posterior parts of the sensorimotor cortex in male C57BL\/6 mice. Mice with ICH under these conditions exhibited significant motor deficits as revealed by beam\u2010walking test. Daily administration of nicotine (1 and 2\u2009mg\/kg), with the first injection given at 3\u2009hr after induction of ICH, improved motor performance of mice in a dose\u2010dependent manner, although nicotine did not alter the volume of hematoma. Immunohistochemical examinations revealed that the number of neurons was drastically decreased within the hematoma region. Nicotine at 2\u2009mg\/kg partially but significantly increased the number of remaining neurons within the hematoma at 3 days after induction of ICH. ICH also resulted in inflammatory activation of microglia\/macrophages in the perihematoma region, and nicotine (1 and 2\u2009mg\/kg) significantly attenuated the increase of microglia. These results suggest that nicotine can provide a therapeutic effect on cortical hemorrhage, possibly via its neuroprotective and anti\u2010inflammatory actions. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24016","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T09:32:44Z","timestamp":1483954364000},"page":"1838-1849","source":"Crossref","is-referenced-by-count":19,"title":["Cortical hemorrhage\u2010associated neurological deficits and tissue damage in mice are ameliorated by therapeutic treatment with nicotine"],"prefix":"10.1002","volume":"95","author":[{"given":"Junpei","family":"Anan","sequence":"first","affiliation":[{"name":"Department of Chemico\u2010Pharmacological Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Hijioka","sequence":"additional","affiliation":[{"name":"Department of 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