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In this review, we first focus on the modifications of ADAMTS\u20104 expression during CNS physiological and pathological conditions, including chronic diseases and injuries. Then, we discuss the contributions of ADAMTS\u20104 to mechanisms mediating neuroplasticity, neuroinflammation and neurodegeneration during spinal cord injury, ischemic stroke, amyotrophic lateral sclerosis and Alzheimer's disease. Here, we provide an overview of ADAMTS\u20104 functions and effects in the CNS, and we discuss directions for future studies and treatments. Overall, this review highlights that ADAMTS\u20104 is a unique multifaceted metalloproteinase which influences various CNS disease pathophysiologies. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24021","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:39:01Z","timestamp":1484325541000},"page":"1703-1711","source":"Crossref","is-referenced-by-count":18,"title":["ADAMTS\u20104 in central nervous system pathologies"],"prefix":"10.1002","volume":"95","author":[{"given":"Sighild","family":"Lemarchant","sequence":"first","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio University of Eastern Finland P.O. BOX 1627 70211 Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio University of Eastern Finland P.O. 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