{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:43:33Z","timestamp":1766486613385,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Defense Autism Spectrum Disorders Research Program","award":["AS073224P2"],"award-info":[{"award-number":["AS073224P2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Monoamine oxidases (MAOs) catalyze the metabolism of monoamine neurotransmitters, such as serotonin, dopamine, and norepinephrine, and are key regulators for brain function. In this study, we analyzed the activities of MAO\u2010A and MAO\u2010B in the cerebellum and frontal cortex from subjects with autism and age\u2010matched control subjects. In the cerebellum, MAO\u2010A activity in subjects with autism (aged 4\u201338 years) was significantly lower by 20.6% than in controls. When the subjects were divided into children (aged 4\u201312 years) and young adults (aged 13\u201338 years) subgroups, a significant decrease by 27.8% in the MAO\u2010A activity was observed only in children with autism compared with controls. When the 95% confidence interval of the control group was taken as a reference range, reduced activity of MAO\u2010A was observed in 70% of children with autism. In the frontal cortex, MAO\u2010A activity in children with autism was also lower by 30% than in the control group, and impaired activity of MAO\u2010A was observed in 55.6% of children with autism, although the difference between the autism and control groups was not significant when all subjects were considered. On the contrary, there was no significant difference in MAO\u2010B activity in both the cerebellum and frontal cortex between children with autism and the control group as well as in adults. These results suggest impaired MAO\u2010A activity in the brain of subjects with autism, especially in children with autism. Decreased activity of MAOs may lead to increased levels of monoaminergic neurotransmitters, such as serotonin, which have been suggested to have a critical role in autism. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24027","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T13:40:54Z","timestamp":1486042854000},"page":"1965-1972","source":"Crossref","is-referenced-by-count":27,"title":["Monoamine oxidase\u2010A and B activities in the cerebellum and frontal cortex of children and young adults with autism"],"prefix":"10.1002","volume":"95","author":[{"given":"Feng","family":"Gu","sequence":"first","affiliation":[{"name":"NYS Institute for Basic Research in Developmental Disabilities Staten Island New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ved","family":"Chauhan","sequence":"additional","affiliation":[{"name":"NYS Institute for Basic Research in Developmental Disabilities Staten Island New 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