{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:27:21Z","timestamp":1780072041859,"version":"3.54.0"},"reference-count":107,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation for the Doctoral Program of Higher Education of China","award":["20124423110002"],"award-info":[{"award-number":["20124423110002"]}]},{"name":"Natural Science Foundation of Guangdong, China","award":["2015A030313461"],"award-info":[{"award-number":["2015A030313461"]}]},{"name":"Project of Science and Technology Program of Guangzhou Bureau of Education, China","award":["1201410359"],"award-info":[{"award-number":["1201410359"]}]},{"name":"PhD research Start-up Foundation of Guangzhou Medical University","award":["2014C30"],"award-info":[{"award-number":["2014C30"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional states of Rab7 generally switch between GTP\u2010bound and GDP\u2010bound states under the control of guanine nucleotide exchange factors (GEFs) and GTPase\u2010activating proteins (GAPs). Activated GTP\u2010Rab7 is capable of regulating autophagosome formation, autophagosome transportation along microtubules, endosome and autophagosome maturation, as well as lysosome biogenesis via interacting with its effector molecules. Rab7\u2010mediated macroautophagy is closely associated with various pathological processes of several neurologic diseases, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, Charcot\u2010Marie\u2010Tooth type 2B disease, and cerebral ischemic diseases. Considering that macroautophagy can be the prime therapeutic target in certain nervous system diseases, in\u2010depth study of Rab7 in the regulation of macroautophagy may be helpful to identify novel strategies for the treatment of autophagy\u2010related neurologic diseases. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24034","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:32:45Z","timestamp":1486733565000},"page":"1993-2004","source":"Crossref","is-referenced-by-count":45,"title":["Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy"],"prefix":"10.1002","volume":"95","author":[{"given":"Haixia","family":"Wen","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4874-6373","authenticated-orcid":false,"given":"En","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012124546-7\/50596-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.417766"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.2.467"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120197"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000229233.75253.be"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1862-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0748-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.26938"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1063-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.133"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600658"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702290104"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.02.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.29616"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.85"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70238-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13712"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.1.1.1270"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.168"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.6.1435"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0320-z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2401-4_7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-08-0693"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0550065"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.024"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101080"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.05.030"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu395"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells5030034"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01114"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.000737"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80380-3"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.04.051"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00059.2009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.11.018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01370"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1147673"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.02.003"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00531-0"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.80"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.191"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1717"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.023"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.295451"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2012.21.1.1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6412-10.2011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2569-8_1"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1740"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6496"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.2.2.15256"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.484253"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016840"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000063107"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.041814"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201106120"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.09.003"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091585"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2010.12.005"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-08-0495"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052810-093700"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00371-06"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.019265"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.3.11419"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2010.02.005"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5054"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.4.11670"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.27311"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.011"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.5.1075"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2009"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.043"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2745"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00915.x"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06562.x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.4.11737"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.12.055"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2569-15.2016"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.4.901"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.67"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-01-0077"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010554107"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29395"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21303"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151156"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3233\/JHD-130081","article-title":"Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice","volume":"3","author":"Vodicka P","year":"2014","journal-title":"J Huntingtons Dis"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-02-0741"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.10.023"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6412"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv415"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.6.1241"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100109-104131"},{"key":"e_1_2_10_98_1","doi-asserted-by":"crossref","first-page":"e01612","DOI":"10.7554\/eLife.01612","article-title":"Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy","author":"Yamano K","year":"2014","journal-title":"eLife"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24633"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0910-814"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.01.013"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.023"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06046.x"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/35052055"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4322-12.2013"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20090032"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.379164"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2010.01086.x"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:13:54Z","timestamp":1696356834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":107,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/jnr.24034"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24034","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}