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This contributes to anxiolysis of stressed animals. Socially isolated adolescent female rats with 8 days of wheel access, the last 4 days of which entail restricted food access, have been shown to exhibit excessive exercise, choosing to run instead of eat (activity\u2010based anorexia [ABA]). Upregulation of \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>Rs in the dorsal hippocampal CA1 (DH), seen among some ABA animals, correlates with suppression of excessive exercise. We used electron microscopic immunocytochemistry to show that exercise alone (EX), but not food restriction alone (FR), also augments \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R expression at axospinous excitatory synapses of the DH (67%, <jats:italic>P<\/jats:italic>\u2009=\u20090.027), relative to socially isolated controls without exercise or food restriction (CON). Relative to CON, ABA animals' synaptic \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R elevation was modestly elevated (37%), but this level correlated strongly and negatively with individual differences in ABA vulnerability\u2014i.e., food restriction\u2013evoked hyperactivity (Pearson <jats:italic>R<\/jats:italic>\u2009=\u2009\u22120.902, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and weight changes (<jats:italic>R<\/jats:italic>\u2009=\u20090.822, <jats:italic>P<\/jats:italic>\u2009=\u20090.012). These correlations were absent from FR and EX brains or ventral hippocampus of ABA brains. Comparison to CON of \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R location in the DH indicated that ABA induces trafficking of \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R from reserve pools in spine cytoplasm to excitatory synapses. Pair\u2010housing CON animals reduced cytoplasmic \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R without reducing synaptic \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>R. Thus, exercise induces trafficking of \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>Rs to excitatory synapses, while individual differences in ABA vulnerability are linked most strongly to trafficking of \u03b14\u03b2\u03b4\u2010GABA<jats:sub>A<\/jats:sub>Rs in the reverse direction\u2014from excitatory synapses to the reserve pool during co\u2010occurring food restriction. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24035","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T11:06:52Z","timestamp":1487588812000},"page":"1450-1466","source":"Crossref","is-referenced-by-count":14,"title":["\u03b14\u03b2\u03b4\u2010GABA<sub>A<\/sub> receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity\u2010based anorexia through localization at excitatory synapses"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-9425","authenticated-orcid":false,"given":"Chiye","family":"Aoki","sequence":"first","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara Gunkali","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Piper","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"535","article-title":"Use of electron microscopy in the detection of adrenergic receptors","volume":"126","author":"Aoki C","year":"2000","journal-title":"Methods Mol Biol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21528"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.01.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02150-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1341-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0612-9"},{"key":"e_1_2_8_11_1","unstructured":"ChowdhuryTG FentonAA AokiC.2015.The effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration. 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