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One\u2010third of world's population is infected with <jats:italic>Toxoplasma gondii<\/jats:italic> (<jats:italic>T. gondii<\/jats:italic>). This intracellular parasite has high tendency to excitable cells including neurons. We assessed seizure susceptibility and involvement of dopaminergic system in male mice with acute and chronic <jats:italic>T. gondii<\/jats:italic> infection. Mice were infected by intraperitoneal injection of <jats:italic>T. gondii<\/jats:italic> cysts. Acute and chronic stages of infection were determined by quantification of SAG1\/BAG1 transcripts and level of repetitive REP\u2010529 sequence in the brain of mice by real\u2010time PCR. Threshold of clonic seizures was measured by tail vein infusion of pentylenetetrazole. The infected mice were pretreated with D1 and D2 dopamine receptor antagonists, and seizure threshold was measured. Moreover, seizure threshold was determined after treatment of toxoplasmosis by sulfamethoxazole and trimethoprim. SAG1 level reached the maximum at week 2 after infection and then declined. The maximum level of BAG1 was observed at the week 3 and preserved till the week 8. REP\u2010529 was detected at first week after infection, reached maximum at the week 3 and kept at this level till the eighth week. Threshold of seizures significantly decreased in both acute and chronic phases of infection. D1 and D2 receptors antagonists inhibited proconvulsant effect of toxoplasmosis. Chemotherapy inhibited parasite growth and multiplication, and returned seizure susceptibility to the level of non\u2010infected mice. Dopaminergic neurotransmission participates in proconvulsant effect of <jats:italic>T. gondii<\/jats:italic>. The effect of parasite is eliminated by antibiotic therapy. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jnr.24036","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T12:22:50Z","timestamp":1488889370000},"page":"1894-1905","source":"Crossref","is-referenced-by-count":13,"title":["Contribution of dopamine neurotransmission in proconvulsant effect of <i>Toxoplasma gondii<\/i> infection in male mice"],"prefix":"10.1002","volume":"95","author":[{"given":"Jalal","family":"Babaie","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Pasteur Institute of Iran Tehran Iran"},{"name":"Molecular Parasitology Laboratory, Department of Parasitology Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-2444","authenticated-orcid":false,"given":"Mohammad","family":"Sayyah","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pezhman","family":"Fard\u2010Esfahani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Golkar","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Department of Parasitology Pasteur Institute of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh","family":"Gharagozli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.12.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02900-14"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12605"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4269\/ajtmh.2009.80.583","article-title":"Cotrimoxazole for treatment of cerebral toxoplasmosis: an observational cohort study during 1994\u20102006","volume":"80","author":"Beraud G","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028925"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2015.07.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00045"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01428-15"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.10.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2015.06.009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00073-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.12691\/ajidm-1-5-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.14411\/fp.2010.013"},{"key":"e_1_2_9_16_1","first-page":"599","article-title":"Tissue cyst rupture in mice chronically infected with toxoplasma gondii","volume":"75","author":"Ferguson DJ","year":"1989","journal-title":"An immunocytochemical and ultrastructural study. 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