{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:55:57Z","timestamp":1777499757538,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS049471"],"award-info":[{"award-number":["NS049471"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS02089"],"award-info":[{"award-number":["NS02089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) is associated with acute cerebral metabolic crisis (ACMC). ACMC\u2010related atrophy appears to be prominent in frontal and temporal lobes following moderate\u2010to\u2010severe TBI. This atrophy is correlated with poorer cognitive outcomes in TBI. The current study investigated ability of acute glucose and lactate metabolism to predict long\u2010term recovery of frontal\u2010temporal cognitive function in participants with moderate\u2010to\u2010severe TBI. Cerebral metabolic rate of glucose and lactate were measured by the Kety\u2010Schmidt method on days 0\u20137 post\u2010injury. Indices of frontal\u2010temporal cognitive processing were calculated for six months post\u2010injury; 12 months post\u2010injury; and recovery (the difference between the six\u2010 and 12\u2010month scores). Glucose and lactate metabolism were included in separate regression models, as they were highly intercorrelated. Also, glucose and lactate values were centered and averaged and included in a final regression model. Models for the prediction frontal\u2010temporal cognition at six and 12 months post\u2010injury were not significant. However, average glucose and lactate metabolism predicted recovery of frontal\u2010temporal cognition, accounting for 23% and 22% of the variance, respectively. Also, maximum glucose metabolism, but not maximum lactate metabolism, was an inverse predictor in the recovery of frontal\u2010temporal cognition, accounting for 23% of the variance. Finally, the average of glucose and lactate metabolism predicted frontal\u2010temporal cognitive recovery, accounting for 22% of the variance. These data indicate that acute glucose and lactate metabolism both support cognitive recovery from TBI. Also, our data suggest that control of endogenous fuels and\/or supplementation with exogenous fuels may have therapeutic potential for cognitive recovery from TBI.<\/jats:p>","DOI":"10.1002\/jnr.24097","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:26:37Z","timestamp":1497374797000},"page":"696-701","source":"Crossref","is-referenced-by-count":22,"title":["Acute glucose and lactate metabolism are associated with cognitive recovery following traumatic brain injury"],"prefix":"10.1002","volume":"96","author":[{"given":"Christina","family":"Mannino","sequence":"first","affiliation":[{"name":"Loma Linda University, Department of Psychology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Glenn","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, Department of Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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