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The aim of the present study is to reveal the imbalance of tryptophan (Trp) and its metabolites in streptozotocin (STZ)\u2010induced experimental DE rats to underscore their critical values in clinical diagnosis of the disease. For this purpose, we first developed an accurate and appropriate simultaneous method for measuring Trp and its metabolites using liquid chromatography\u2013tandem mass spectrometry, which was in accordance with the requirements of biological sample analysis. Secondly, a single STZ intraperitoneal injection was administered to male Sprague\u2013Dawley rats, and their cognitive function was detected by Morris water maze tests. Cerebrospinal fluid (CSF), serum, and brain tissue were then collected for the determination of Trp and its metabolites. Compared with age\u2010matched control rats, the levels of neuroprotective serotonin decreased significantly in the samples of cortices, hippocampi, striatum, CSF, and serums in the STZ\u2010induced DE rats, while the levels of neurotoxic 3\u2010hydroxykynurenine increased significantly. Moreover, analogous changes of both compounds were found in the central nervous system and peripheral blood of the STZ\u2010induced DE rats. In conclusion, we established a quantitative method for the simultaneous detection of Trp and its metabolites, and we also present a critical elucidation of the nervous system dysfunction in DE.<\/jats:p>","DOI":"10.1002\/jnr.24098","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T17:22:37Z","timestamp":1497374557000},"page":"138-150","source":"Crossref","is-referenced-by-count":22,"title":["Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat"],"prefix":"10.1002","volume":"96","author":[{"given":"Xiaowen","family":"Han","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjun","family":"Min","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zejun","family":"Bao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitope Isaac","family":"Adelusi","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-9842","authenticated-orcid":false,"given":"Xueyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxing","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S6225"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64062607.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.02.049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.186"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70021-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70284-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4058580"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.198971"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-017-0785-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.09.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9914869"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.03.120"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.07.014"},{"key":"e_1_2_9_15_1","first-page":"4","article-title":"Characteristics and peculiarities of the course of encephalopathy in diabetes mellitus","volume":"110","author":"Chuiko M. 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