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This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 years of age. However, the developmental period from birth to 18 years is also a time of tremendous brain changes. Therefore, it is important to establish the degree of age\u2010 and sex\u2010related differences. Participants were children aged 8\u201315 years with mTBI or mild orthopedic injuries. Imaging was obtained within 10 days of injury. We performed tract\u2010based spatial statistics (TBSS), deterministic tractography using Automated Fiber Quantification (AFQ), and probabilistic tractography using TRACULA (TRActs Constrained by UnderLying Anatomy) to evaluate whether any method provided improved sensitivity at identifying group, developmental, and\/or sex\u2010related differences. Although there were no group differences from any of the three analyses, many of the tracts, but not all, revealed increases of fractional anisotropy and decreases of axial, radial, and mean diffusivity with age. TBSS analyses resulted in age\u2010related changes across all white matter tracts. AFQ and TRACULA revealed age\u2010related changes within the corpus callosum, cingulum cingulate, corticospinal tract, inferior and superior longitudinal fasciculus, and uncinate fasciculus. The results are in many ways consistent across all three methods. However, results from the tractography methods provided improved sensitivity and better tract\u2010specific results for identifying developmental and sex\u2010related differences within the brain.<\/jats:p>","DOI":"10.1002\/jnr.24142","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T11:42:40Z","timestamp":1507290160000},"page":"626-641","source":"Crossref","is-referenced-by-count":41,"title":["Age\u2010 and sex\u2010related effects in children with mild traumatic brain injury on diffusion magnetic resonance imaging properties: A comparison of voxelwise and tractography methods"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-2910","authenticated-orcid":false,"given":"Naomi J.","family":"Goodrich\u2010Hunsaker","sequence":"first","affiliation":[{"name":"Department of Psychology Brigham Young University Provo Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy J.","family":"Abildskov","sequence":"additional","affiliation":[{"name":"Department of Psychology Brigham Young University Provo Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Black","sequence":"additional","affiliation":[{"name":"Ohio State University Fisher College of Business Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Bigler","sequence":"additional","affiliation":[{"name":"Department of Psychology Brigham Young University Provo Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Nationwide Children's Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie K.","family":"Mihalov","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Nationwide Children's Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Bangert","sequence":"additional","affiliation":[{"name":"Department of Radiology Case Western Reserve University School of Medicine Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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