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Of the four different GluN2 subunits, the GluN2D subunit\u2010containing NMDARs have been suggested as a target for antiparkinsonian therapy because of their expression pattern in some of the basal ganglia nuclei that show abnormal firing patterns in the parkinsonian state, specifically the subthalamic nucleus (STN). In this study, we demonstrate that blockade of NMDARs altered spike firing in the STN in a male nonhuman primate that had been rendered parkinsonian by treatment with the neurotoxin 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine. In accompanying experiments in male rodents, we found that GluN2D\u2010NMDAR expression in the STN was reduced in acutely or chronically dopamine\u2010depleted animals. Taken together, our data suggest that blockade of NMDARs in the STN may be a viable antiparkinsonian strategy, but that the ultimate success of this approach may be complicated by parkinsonism\u2010associated changes in NMDAR expression in the STN.<\/jats:p>","DOI":"10.1002\/jnr.24230","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:34:10Z","timestamp":1522028050000},"page":"1324-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-0699","authenticated-orcid":false,"given":"Subhrajit","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Pharmacology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxian","family":"Ma","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy R.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Bradner","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Scimemi","sequence":"additional","affiliation":[{"name":"Department of Biology State University of New York at Albany Albany New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-9615","authenticated-orcid":false,"given":"Stephen F.","family":"Traynelis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wichmann","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center Emory University Atlanta Georgia"},{"name":"Department of Neurology Emory University School of Medicine Atlanta Georgia"},{"name":"Morris K. 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