{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T19:56:47Z","timestamp":1772481407169,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcranial direct current stimulation (tDCS) has the capacity to enhance force output during a short\u2010lasting maximal voluntary contraction (MVC) as well as during a long\u2010lasting submaximal voluntary contraction until task failure. However, its effect on an intermittent maximal effort is not known. We hypothesized that anodal tDCS applied during or before a maximal fatigue task increases the amplitude of maximal voluntary contraction (aMVC) and voluntary activation (VA) in young healthy male participants. We measured VA, potentiated twitch at rest (Ptw), root mean square electromyogram (EMG), and aMVC during a fatiguing task that consisted of 35 \u00d7 5 s MVC of knee extensors and was performed during tDCS or 10 min after the end of tDCS (sham, anodal, or cathodal treatments). No effect of tDCS was detected on the first MVC but, when compared to sham tDCS, both anodal tDCS and cathodal tDCS reduced aMVC when tDCS was applied during the task (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and only anodal tDCS reduced aMVC when applied 10 min before the task (<jats:italic>p<\/jats:italic>\u2009=\u2009.03). The reductions in aMVC were accompanied by reductions in EMG of M. vastus lateralis for both tDCS treatments as well as in Ptw only during anodal tDCS and in VA only during cathodal tDCS. Both cathodal tDCS and anodal tDCS impaired force production during an intermittent fatiguing MVC task. The detrimental effects were stronger when tDCS was applied during the task. Here, cathodal and anodal tDCS specifically affected Ptw and VA indicating different underlying mechanisms.<\/jats:p>","DOI":"10.1002\/jnr.24254","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T07:31:49Z","timestamp":1524727909000},"page":"1600-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Anodal and cathodal transcranial direct current stimulation can decrease force output of knee extensors during an intermittent MVC fatiguing task in young healthy male participants"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-8225","authenticated-orcid":false,"given":"Louis\u2010Solal","family":"Giboin","sequence":"first","affiliation":[{"name":"Sensorimotor Performance Lab, Universit\u00e4t Konstanz Konstanz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Gruber","sequence":"additional","affiliation":[{"name":"Sensorimotor Performance Lab, Universit\u00e4t Konstanz Konstanz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.10.028"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.249730"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.07.031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05633.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00482.2017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2014.08.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5604\/20831862.1221830"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.4.1725"},{"key":"e_1_2_11_12_1","article-title":"Neuroplasticity following short\u2010term strength training occurs at supraspinal level and is specific for the trained task","author":"Giboin L. 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