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Some of its rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While they all share common features of progressive retinal ganglion cell (RGC) loss, optic nerve damage and corresponding visual field loss, the exact mechanisms underlying glaucomatous neuron loss are not clear. This has largely hindered the development of a real cure for this disease. Elevated intraocular pressure (IOP) is a known major risk factor of glaucoma; however, progressive degeneration of RGCs and axons can also be found in patients with a normal IOP, i.e., normal tension glaucoma (NTG). Interestingly, patients who carry the gain\u2010of\u2010function mutation of the pro\u2010inflammatory gene TBK1 \u2013 tumor necrosis factor (TNF) receptor associated factor NF\u2010\u03baB activator (TANK) binding kinase 1 \u2013 are at increased risk to develop NTG. This finding suggests a causal link between neuroinflammatory processes and glaucoma. Various studies have reported the presence of neuroinflammatory responses by microglia, astrocytes and other blood\u2010born immune cells in the optic nerve head (ONH) at early stages of experimental glaucoma. Inhibition of certain pro\u2010inflammatory pathways, particularly those associated with microglial activation, appears to be neuroprotective. In this review, we will focus on the inflammatory responses, in particular the proposed roles of microglia, in the pathogenesis of glaucoma.<\/jats:p>","DOI":"10.1002\/jnr.24256","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T08:44:57Z","timestamp":1526633097000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":207,"title":["Neuroinflammation and microglia in glaucoma: time for a paradigm shift"],"prefix":"10.1002","volume":"97","author":[{"given":"Xin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Ophthalmology West China Hospital, Sichuan University Chengdu China"},{"name":"Department of Ophthalmology, Harvard Medical School Schepens Eye Research Institute of Massachusetts Eye and Ear Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-615X","authenticated-orcid":false,"given":"Kin\u2010Sang","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School Schepens Eye Research Institute of Massachusetts Eye and Ear Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F.","family":"Thee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School Schepens Eye Research Institute of Massachusetts Eye and Ear Boston Massachusetts"},{"name":"Department of Ophthalmology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-8843","authenticated-orcid":false,"given":"Dong Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School Schepens Eye Research Institute of Massachusetts Eye and Ear Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.04.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1123"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.73695"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.01.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043602"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1337"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018788"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09788"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80781-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3599"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-004-0046-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-98"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00362"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1524-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5284"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026317"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr123"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.02.055"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.07.012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-82"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017659"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.001"},{"issue":"17","key":"e_1_2_7_26_1","first-page":"30281","article-title":"The role of astrocytes in multiple sclerosis pathogenesis","volume":"0213","author":"Guerrero\u2010Garcia J. 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