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Moreover, most of these subjects also show impairment in social cognition, which is a comprehensive array of function that guides social interaction with the others, leading as well to the acquisition of new cognitive and social skills. In the last decade researchers have argued whether social cognition dysfunctions could be underlined by specific genetic alterations, and whether these are linked to specific clinical features. Some valid candidate genes are RTN4R, that encodes a protein which inhibits axonal sprouting, DGCR8, crucial in mRNA processing, or catechol\u2010O\u2010methyltransferase (COMT) and proline oxydase 1 (PRODH), involved in catecholamine metabolism in frontal cortex. This is the first article to address the topic of social cognition in 22q11.2 DS from a wide perspective, with a highlight on its genetic characteristics. We will provide a narrative review of the most recent findings and we will point out new directions on this research path, in order to achieve an effective characterization of the neurobiological system underlying social behavior.<\/jats:p>","DOI":"10.1002\/jnr.24265","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T12:23:18Z","timestamp":1531484598000},"page":"1631-1640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genetic and clinical features of social cognition in 22q11.2 deletion syndrome"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-683X","authenticated-orcid":false,"given":"Guido Maria","family":"Lattanzi","sequence":"first","affiliation":[{"name":"Department of Human Neurosciences Sapienza University Rome 00185 Italy"},{"name":"Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience, King's College London SE5 8AF United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Buzzanca","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Frascarelli","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Fabio","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University Rome 00185 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163514"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.022"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"333","article-title":"Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: A 3\u2010year follow\u2010up study","volume":"49","author":"Antshel K. 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