{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:34:13Z","timestamp":1789176853137,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Children with cerebral palsy often present with cognitive\u2010visual dysfunctions characterized by visuo\u2010perceptual and\/or visuo\u2010spatial deficits associated with a malfunctioning of visual\u2010associative areas.<\/jats:p>\n                  <jats:p>The neurofunctional model of this condition remains poorly understood due to the lack of a clear correlation between cognitive\u2010visual deficit and morphological brain anomalies. The aim of our study was to quantify the pattern of white matter abnormalities within the whole brain in children with cerebral palsy, and to identify white matter tracts sub\u2010serving cognitive\u2010visual functions, in order to better understand the basis of cognitive\u2010visual processing.<\/jats:p>\n                  <jats:p>Nine subjects (three males, mean age 8 years 9 months) with cerebral palsy underwent a visual and cognitive\u2010visual evaluation. Conventional brain MRI and diffusion tensor imaging were performed. The fractional anisotropy maps were calculated for every child and compared with data from 13 (four males, mean age 10 years 7 months) healthy children.<\/jats:p>\n                  <jats:p>Children with cerebral palsy showed decreased fractional anisotropy (a marker of white matter integrity) in corticospinal tract bilaterally, left superior longitudinal fasciculus and bilateral hippocampus. Focusing on the superior longitudinal fasciculus, the mean fractional anisotropy values were significantly lower in children affected by cerebral palsy with cognitive\u2010visual deficits than in those without cognitive\u2010visual deficits.<\/jats:p>\n                  <jats:p>Our findings reveal an association between cognitive\u2010visual profile and the superior longitudinal fasciculus integrity in children with cerebral palsy, supporting the hypothesis that visuo\u2010associative deficits are related to changes in fibers connecting the occipital cortex with the parietal\u2010frontal cortices. Decreased fractional anisotropy within the superior longitudinal fasciculus could be considered a biomarker for cognitive\u2010visual dysfunctions.<\/jats:p>","DOI":"10.1002\/jnr.24307","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T01:29:15Z","timestamp":1532050155000},"page":"1766-1774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["White matter changes associated with cognitive visual dysfunctions in children with cerebral palsy: A diffusion tensor imaging study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-7548","authenticated-orcid":false,"given":"Jessica","family":"Galli","sequence":"first","affiliation":[{"name":"Clinical and Experimental Sciences Department, University of Brescia Italy"},{"name":"Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ambrosi","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, ASST Spedali Civili of Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Micheletti","sequence":"additional","affiliation":[{"name":"Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotfi B.","family":"Merabet","sequence":"additional","affiliation":[{"name":"The Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pinardi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, ASST Spedali Civili of Brescia Italy"},{"name":"Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fazzi","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences Department, University of Brescia Italy"},{"name":"Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4717"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"NA","DOI":"10.1002\/hipo.20641","article-title":"Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint","volume":"20","author":"Barense M. 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