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The underlying mechanisms, including the possible role of the circadian timing system, are not well established. The BACHD mouse model of HD exhibits disrupted behavioral and physiological rhythms, including decreased electrical activity in the central circadian clock (suprachiasmatic nucleus, SCN). In this study, electrophysiological techniques were used to explore the ionic underpinning of the reduced spontaneous neural activity in male mice. We found that SCN neural activity rhythms were lost early in the disease progression and was accompanied by loss of the normal daily variation in resting membrane potential in the mutant SCN neurons. The low neural activity could be transiently reversed by direct current injection or application of exogenous N\u2010methyl\u2010d\u2010aspartate (NMDA) thus demonstrating that the neurons have the capacity to discharge at WT levels. Exploring the potassium currents known to regulate the electrical activity of SCN neurons, our most striking finding was that these cells in the mutants exhibited an enhancement in the large\u2010conductance calcium activated K<jats:sup>+<\/jats:sup> (BK) currents. The expression of the pore forming subunit (<jats:italic>Kcnma1<\/jats:italic>) of the BK channel was higher in the mutant SCN. We found a similar decrease in daytime electrical activity and enhancement in the magnitude of the BK currents early in disease in another HD mouse model (Q175). These findings suggest that SCN neurons of both HD models exhibit early pathophysiology and that dysregulation of BK current may be responsible.<\/jats:p>","DOI":"10.1002\/jnr.24320","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T14:57:22Z","timestamp":1535727442000},"page":"1862-1875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington\u2019s disease"],"prefix":"10.1002","volume":"96","author":[{"given":"Dika","family":"Kuljis","sequence":"first","affiliation":[{"name":"Department of Neurobiology University of California Los Angeles Los Angeles California"},{"name":"Department of Biological Sciences, Mellon Institute Carnegie Mellon University Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences University of California Los Angeles Los Angeles California"},{"name":"Okinawa Institute of Science and Technology Graduate University Onna\u2010son Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-6185","authenticated-orcid":false,"given":"Cristina A.","family":"Ghiani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences University of California Los Angeles Los Angeles California"},{"name":"Department of Pathology and Laboratory Medicine University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-184X","authenticated-orcid":false,"given":"Christopher S.","family":"Colwell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027714"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00791.2004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.02.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5196-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"Block G. 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