{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:33:44Z","timestamp":1768034024810,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (C)","award":["15K0931607"],"award-info":[{"award-number":["15K0931607"]}]},{"name":"Grant-in-Aid for Scientific Research (C)","award":["17H0419619"],"award-info":[{"award-number":["17H0419619"]}]},{"name":"Grant-in-Aid for Scientific Research (C)","award":["17K1082709"],"award-info":[{"award-number":["17K1082709"]}]},{"name":"Grant-in-Aid for Scientific Research (B)","award":["17H0419619"],"award-info":[{"award-number":["17H0419619"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Stachybotrys microspora<\/jats:italic> triprenyl phenol (SMTP)\u201044D has both anti\u2010oxidative and anti\u2010inflammatory activities, but its efficacy has not been proved in relation to the pathological changes of neurovascular unit (NVU) and neurovascular trophic coupling (NVTC) in ischemic stroke. Here, the present study was designed to assess the efficacies of SMTP\u201044D, moreover, compared with the standard neuroprotective reagent edaravone in ischemic brains. ICR mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 60\u00a0min, SMTP\u201044D (10\u00a0mg\/kg) or edaravone (3\u00a0mg\/kg) was intravenously administrated through subclavian vein just after the reperfusion, and these mice were examined at 1, 3, and 7 d after reperfusion. Compared with the vehicle group, SMTP\u201044D treatment revealed obvious ameliorations in clinical scores and infarct volume, meanwhile, markedly suppressed the accumulations of 4\u2010HNE, 8\u2010OHdG, nitrotyrosine, RAGE, TNF\u2010\u03b1, Iba\u20101, and cleaved caspase\u20103 after tMCAO. In addition, SMTP\u201044D significantly prevented the dissociation of NVU and improved the intensity of NAGO\/BDNF and the number of BDNF\/TrkB and BDNF\/NeuN double positive cells. These effects of SMTP\u201044D in reducing oxidative and inflammatory stresses were similar to or stronger than those of edaravone. The present study demonstrated that SMTP\u201044D showed strong anti\u2010oxidative, anti\u2010inflammatory, and anti\u2010apoptotic effects, moreover, the drug also significantly improved the NVU damage and NVTC in the ischemic brain.<\/jats:p>","DOI":"10.1002\/jnr.24326","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T13:15:26Z","timestamp":1537622126000},"page":"1887-1899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neuroprotective effects of SMTP\u201044D in mice stroke model in relation to neurovascular unit and trophic coupling"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8806-8226","authenticated-orcid":false,"given":"Xiaowen","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Morihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Hishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hasumi","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo Noko University Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200010000-00001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1992.11740089"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.4.480"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.018"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"339","article-title":"Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression","volume":"147","author":"Augustin H. G.","year":"1995","journal-title":"American Journal of Pathology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.3.472"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.6.1124"},{"key":"e_1_2_9_9_1","first-page":"201","article-title":"Brain synthesis and cerebrovascular action of cytochrome P\u2010450\/monooxygenase metabolites of arachidonic acid","volume":"21","author":"Ellis E. F.","year":"1991","journal-title":"Advances in Prostaglandin, Thromboxane, and Leukotriene Research"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801105105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10131FP"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07783.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.11.1389"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.07.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.32"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0230-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.29"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.01.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0670-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.588087"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598359"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199601000-00011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24047"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100439200"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21747"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03366-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2009.5.3.126"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.191"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22776"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151126"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.055"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-010-0542-5"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008106200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2009.04.007"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.12.1094"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2109"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.164"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0149-06.2006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.60.2.310"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00783.2006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.06.046"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.992"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000037787.07479.9A"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225014058"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00114-0"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T00:35:39Z","timestamp":1694910939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,22]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/jnr.24326"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24326","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,22]]},"assertion":[{"value":"2018-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}